Evidence map›Paper›PMID 33118849›Full record

ArticleJournal of feline medicine and surgery2021

Stem cell therapy prior to full-mouth tooth extraction lacks substantial clinical efficacy in cats affected by chronic gingivostomatitis.

Boaz Arzi, Nopmanee Taechangam, Milinda J Lommer, Naomi J Walker, Megan R Loscar, Dori L Borjesson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of feline medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Mesenchymal Stem Cells in Veterinary Medicine-Still Untapped Potential.Animals : an open access journal from MDPI · 2025
    Review
  6. The prevalence of reasons for tooth extraction in cats.Frontiers in veterinary science · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Boaz ArziDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.ORCID 0000-0002-7289-8994
Nopmanee TaechangamVeterinary Institute for Regenerative Cures, School of Veterinary Medicine, University of California, Davis, CA, USA.
Milinda J LommerDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Naomi J WalkerVeterinary Institute for Regenerative Cures, School of Veterinary Medicine, University of California, Davis, CA, USA.
Megan R LoscarWilliam R Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.
Dori L BorjessonVeterinary Institute for Regenerative Cures, School of Veterinary Medicine, University of California, Davis, CA, USA.
Veterinary Medical Teaching Hospital · USUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this pilot study was to determine the safety, efficacy and immunomodulatory function of systemically administered adipose-derived mesenchymal stem cells (ASCs) in cats affected by feline chronic gingivostomatitis (FCGS) prior to full-mouth tooth extractions.

methodsFive client-owned cats affected with FCGS that did not undergo full-mouth tooth extractions for FCGS treatment received two intravenous injections of 20 million fresh, allogeneic or autologous ASCs. An oral examination with photographs, a complete blood count, blood immune cell phenotyping and a biochemical profile were completed at 0 and 6 months after treatment.

resultsFour cats completed the study and one cat exited the study 3 months after treatment. While the treatment was determined to be clinically safe, no positive clinical response was observed in three cats and a mild response was noted in two cats. Furthermore, none of the cats exhibited immune modulation, as evidenced by no alteration in circulating CD8 CONCLUSIONS AND RELEVANCE: Unlike the reported efficacy of ASCs in treating cats with non-responsive FCGS after full-mouth tooth extraction, the systemic administration of ASCs prior to full-mouth tooth extraction lacks substantial clinical efficacy and is not recommended at this time.

Indexed as

Cat DiseasesCD8-Positive T-LymphocytesAnimalsCatsCell- and Tissue-Based TherapyMouthPilot ProjectsTooth ExtractionTreatment OutcomeAdipose-derived mesenchymal stem cellsearly interventionefficacygingivostomatitissafety

Identifiers

PMID33118849
PMCPMC10741287
OpenAlexW3094634493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.