Evidence map›Paper›PMID 33118634›Full record

ArticleThe EMBO journal2020

Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9.

Iven Winklemann, Rei Matsuoka, Pascal F Meier, Denis Shutin, Chenou Zhang, Laura Orellana, Ricky Sexton, Michael Landreh, Carol V Robinson, Oliver Beckstein and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
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  7. Review
  8. Review
  9. Structure and Inhibition of the Human NaInternational journal of molecular sciences · 2025
    Article
  10. PIPNature communications · 2025
    Article
  11. Article
  12. Article
  13. The vacuolar KScience advances · 2024
    Article
  14. Structure and mechanism of the KNature communications · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Iven Winklemann *Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Rei Matsuoka *Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Pascal F Meier *Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Denis ShutinDepartment of Chemistry, University of Oxford, Oxford, UK.
Chenou ZhangDepartment of Physics, Center for Biological Physics, Arizona State University, Tempe, AZ, USA.
Laura OrellanaDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Ricky SextonDepartment of Physics, Center for Biological Physics, Arizona State University, Tempe, AZ, USA.
Michael LandrehDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-7958-4074
Carol V RobinsonDepartment of Chemistry, University of Oxford, Oxford, UK.
Oliver BecksteinDepartment of Physics, Center for Biological Physics, Arizona State University, Tempe, AZ, USA.
David DrewDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID 0000-0001-8866-6349
Stockholm University · SEArizona State University · USUniversity of Oxford · GBKarolinska Institutet · SE

Funding

Molecular mechanisms of secondary active transportersR01GM118772 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI BECKSTEIN, OLIVER · 2016 to 2020
$1.5M
NIGMS NIH HHS R01 GM118772Wellcome Trust
6 · The paper itself

Abstract

Na

Indexed as

AnimalsBinding SitesBrainCell MovementCryoelectron MicroscopyEndosomesHorsesMolecular Dynamics SimulationMutationProtein ConformationProtein IsoformsProtein TransportProtonsSequence AlignmentSodiumSodium-Hydrogen ExchangersProtein IsoformsProtonsSLC9A9 protein, humanSodiumSodium-Hydrogen Exchangers

Identifiers

PMID33118634
PMCPMC7737618
OpenAlexW3095515890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.