Evidence map›Paper›PMID 33118611›Full record

ArticleBiotechnology and bioengineering2021

Scaffolds obtained from decellularized human extrahepatic bile ducts support organoids to establish functional biliary tissue in a dish.

Jorke Willemse, Floris J M Roos, Iris J Voogt, Ivo J Schurink, Marcel Bijvelds, Hugo R de Jonge, Luc J W van der Laan, Jeroen de Jonge, Monique M A Verstegen

Open access · hybridAbstract read
In one paragraph

Article in Biotechnology and bioengineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jorke WillemseDepartment of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-2167-1279
Floris J M RoosDepartment of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-1278-6517
Iris J VoogtDepartment of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Ivo J SchurinkDepartment of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Marcel BijveldsDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-0814-188X
Hugo R de JongeDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-7596-7433
Luc J W van der LaanDepartment of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-0651-5334
Jeroen de JongeDepartment of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Monique M A VerstegenDepartment of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-9908-6673
Erasmus MC · NL

Funding

Erasmus MC Mrace PhD ProjectMedical Delta Regenerative Medicine 4DMLDS-Diagnostiek Grant D16-26
6 · The paper itself

Abstract

Biliary disorders can lead to life-threatening disease and are also a challenging complication of liver transplantation. As there are limited treatment options, tissue engineered bile ducts could be employed to replace or repair damaged bile ducts. We explored how these constructs can be created by seeding hepatobiliary LGR5

Indexed as

Tissue EngineeringBile Ducts, ExtrahepaticEpithelial CellsExtracellular MatrixHumansOrganoidsTissue Scaffoldsdecellularizationextrahepatic bile ductLGR5+ organoidspersonalized regenerative medicinetissue engineering

Identifiers

PMID33118611
PMCPMC7894321
OpenAlexW3097610187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.