ArticleJournal of biomedical optics2020
Label-free imaging of lipid-rich biological tissues by mid-infrared photoacoustic microscopy.
Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Revealing hidden tissue architecture with mid-infrared dichroism photoacoustic microscopy.Light, science & applications · 2026Article
- Recent advancements in molecular photoacoustic tomography.JPhys photonics · 2025Review
- Ultrasensitive in vivo infrared spectroscopic imaging via oblique photothermal microscopy.Nature communications · 2025Article
- Controlling the sound of light: photoswitching optoacoustic imaging.Nature methods · 2024Review
- Mid-infrared photoacoustic brain imaging enabled by cascaded gas-filled hollow-core fiber lasers.Neurophotonics · 2024Article
- Optical-resolution photoacoustic microscopy with a needle-shaped beam.Nature photonics · 2023Article
- Label-free analytic histology of carotid atherosclerosis by mid-infrared optoacoustic microscopy.Photoacoustics · 2022Article
- Nanosecond SRS fiber amplifier for label-free near-infrared photoacoustic microscopy of lipids.Photoacoustics · 2022Article
- Non-Invasive Monitoring of Human Health by Photoacoustic Spectroscopy.Sensors (Basel, Switzerland) · 2022Review
- In Vivo Quantitative Vasculature Segmentation and Assessment for Photodynamic Therapy Process Monitoring Using Photoacoustic Microscopy.Sensors (Basel, Switzerland) · 2021Article
- Pilot Study: Quantitative Photoacoustic Evaluation of Peripheral Vascular Dynamics Induced by Carfilzomib In Vivo.Sensors (Basel, Switzerland) · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
significanceMid-infrared (IR) imaging based on the vibrational transition of biomolecules provides good chemical-specific contrast in label-free imaging of biology tissues, making it a popular tool in both biomedical studies and clinical applications. However, the current technology typically requires thin and dried or extremely flat samples, whose complicated processing limits this technology's broader translation.
aimTo address this issue, we report mid-IR photoacoustic microscopy (PAM), which can readily work with fresh and thick tissue samples, even when they have rough surfaces. APPROACH: We developed a transmission-mode mid-IR PAM system employing an optical parametric oscillation laser operating in the wavelength range from 2.5 to 12 μm. Due to its high sensitivity to optical absorption and the low ultrasonic attenuation of tissue, our PAM achieved greater probing depth than Fourier transform IR spectroscopy, thus enabling imaging fresh and thick tissue samples with rough surfaces.
resultsIn our spectroscopy study, the CH2 symmetric stretching at 2850 cm - 1 (3508 nm) was found to be an excellent source of endogenous contrast for lipids. At this wavenumber, we demonstrated label-free imaging of the lipid composition in fresh, manually cut, and unprocessed tissue sections of up to 3-mm thickness.
conclusionsOur technology requires no time-consuming sample preparation procedure and has great potential in both fast clinical histological analysis and fundamental biological studies.
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