ArticleActa neurochirurgica2021
Interleukin-6 as inflammatory marker of surgical site infection following spinal surgery.
Article in Acta neurochirurgica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 18 citations in OpenAlex.
- Clinical utility of metagenomic next-generation sequencing in diagnosing spinal infections: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Postoperative laboratory markers as predictors of early spinal surgical site infections: A retrospective cohort study.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Clinical application value of nanopore-targeted sequencing technology for primary spine infection: a mulicenter, retrospective observational study.BMC infectious diseases · 2025Observational
- Machine learning-based prognostic model for bloodstream infections in hematological malignancies using Th1/Th2 cytokines.BMC infectious diseases · 2025Article
- Construction of a logistic model and GBM model for infection after spinal canal resection of intraspinal tumors.American journal of translational research · 2025Article
- Interleukin-6 as a critical inflammatory marker for early diagnosis of surgical site infection after spine surgery.Infection · 2024Article
- Radiation-Induced miRNAs Changes and cf mtDNA Level in Trauma Surgeons: Epigenetic and Molecular Biomarkers of X-ray Exposure.International journal of molecular sciences · 2024Article
- Serum IL-6 as a Surrogate Biomarker of Post-operative Complications in Invasive Orthopaedic Surgeries: A Prospective Observational Study.Indian journal of orthopaedics · 2024Article
- Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection.BMC surgery · 2024Article
- Surgical site infection in spinal surgery: a bibliometric analysis.Journal of orthopaedic surgery and research · 2023Article
- A prospective study to identify preoperative serum parameters for spinal implant infection detected by sonication fluid culture.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- The Inflammatory Biomarkers Behavior Profile of Patients Following Elective Degenerative Spine Surgery and Differences Compared to Those Coursing With a Postoperative Spinal Infection: Protocol for a Systematic Review.JMIR research protocols · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn order to elucidate whether serum inflammatory markers identify patients with local surgical site infection(SSI) as underlying disease for recurrent or new symptomatology following spine surgery, we evaluated the diagnostic potential of interleukin-6(IL-6) as a marker of SSI. The diagnostic significance of IL-6 was compared to the standard serum inflammatory markers C-reactive protein(CRP) and white blood cell count (WBCC).
methodNinety-eight consecutive patients with readmission due to recurrent or new symptomology after spinal surgery of degenerative spine disorders entered the study. Baseline patients' characteristics and the abovementioned inflammatory markers were collected, and arithmetical means with standard deviation, area under the curve (AUC), thresholds, sensitivity, specificity, positive(+)likelihood ratio (LR), and negative(-)LR with corresponding 95% confidence interval(95%CI) were calculated and correlated with presence or absence of SSI.
resultsNine patients suffered from a SSI, whereas the remaining 89 patients had a recurrent/adjacent-segment degenerative disorder without evidence of infection. The most significant parameter for diagnosing a SSI was serum IL-6 (cut-off value > 15.3 pg/ml, AUC = 0.954, SE = 85.7%, SP = 97.3%), followed by CRP (cut-off value = 0.8 mg/dl, AUC = 0.916, SE = 88.9%, SP = 84.5%)
conclusionsIn the case of recurrent or new symptomatology following spinal surgery, serum IL-6 has the highest diagnostic potential for diagnosing spinal SSI.
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