ArticleAlzheimer's & dementia (New York, N. Y.)2020
Associations of equol-producing status with white matter lesion and amyloid-β deposition in cognitively normal elderly Japanese.
Article in Alzheimer's & dementia (New York, N. Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- An inverse association of cerebral amyloid-β deposition and serum docosahexaenoic acid levels in cognitively normal older adults in Japan.Journal of Alzheimer's disease : JAD · 2025Article
- Equol Nonproducing Status as an Independent Risk Factor for Acute Cardioembolic Stroke and Poor Functional Outcome.Nutrients · 2024Article
- The relationship between equol production status and normal tension glaucoma.International ophthalmology · 2024Article
- The Role of Diet as a Modulator of the Inflammatory Process in the Neurological Diseases.Nutrients · 2023Review
- Cross-sectional association of equol producing status with aortic calcification in Japanese men aged 40-79 years.Scientific reports · 2022Article
- Potential Protective Mechanisms of S-equol, a Metabolite of Soy Isoflavone by the Gut Microbiome, on Cognitive Decline and Dementia.International journal of molecular sciences · 2022Review
- Modifiable Innate Biology within the Gut-Brain Axis for Alzheimer's Disease.Biomedicines · 2022Review
- Association of equol producing status with aortic calcification in middle-aged Japanese men: The ERA JUMP study.International journal of cardiology · 2022Article
- The health effects of soy: A reference guide for health professionals.Frontiers in nutrition · 2022Review
- Associations of equol-producing status with white matter lesion and amyloid-β deposition in cognitively normal elderly Japanese.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Current perspectives on prevention of vascular cognitive impairment and promotion of vascular brain health.Expert review of neurotherapeuticsReview
- ACE trial design: Equol targeting estrogen receptor-β in vascular and cognitive aging.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
- Erratum issuedErratum.2021
Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionEquol, a metabolite of a soy isoflavone transformed by the gut microbiome, is anti-oxidant and anti-amyloidogenic. We assessed the associations of equol with white matter lesion normalized to total brain volume (WML%) and amyloid beta (Aβ) deposition.
methodsFrom 2016 to 2018, 91 cognitively normal elderly Japanese aged 75 to 89 underwent brain magnetic resonance imaging and positron emission tomography using
resultsThe median (interquartile range) WML% was 1.10 (0.59 to 1.61); 24.2% were Aβ positive, and 51% were equol producers. Equol-producing status (non-producers, low and high) was significantly inversely associated with WML%: 1.19, 0.89, and 0.58, respectively (trend DISCUSSION: A randomized-controlled trial of equol targeting WML volume is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.