Evidence map›Paper›PMID 33117820›Full record

ArticleFrontiers in cell and developmental biology2020

miR-766-3p Targeting BCL9L Suppressed Tumorigenesis, Epithelial-Mesenchymal Transition, and Metastasis Through the β-Catenin Signaling Pathway in Osteosarcoma Cells.

Sheng Zhang, Hongtao Chen, Wanshun Liu, Le Fang, Zhanyang Qian, Renyi Kong, Qi Zhang, Juming Li, Xiaojian Cao

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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  12. Frontiers in genetics · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sheng ZhangDepartment of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hongtao ChenDepartment of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wanshun LiuDepartment of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Le FangDepartment of Critical Care Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhanyang QianDepartment of Orthopedics, The Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
Renyi KongDepartment of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Qi ZhangDepartment of Painology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Juming LiDepartment of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xiaojian CaoDepartment of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jiangsu Province Hospital · CNNanjing Medical University · CNZhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence has indicated that abnormal microRNAs (miRNAs) serve critical roles in carcinogenesis and development of osteosarcoma (OS). The purpose of the present study was to elucidate the relationship between miR-766-3p and development of osteosarcoma and explore the potential mechanism. In this study, we found that miR-766-3p was the most downregulated miRNA by analyzing GSE65071 from the GEO database. miR-766-3p was lowly expressed in OS tissue samples and cells, and high miR-766-3p expression repressed the malignant level of OS, including cell proliferation, EMT, migration, and invasion

Indexed as

BCL9LEMTmetastasismiR-766-3posteosarcomaβ-catenin

Identifiers

PMID33117820
PMCPMC7575756
OpenAlexW3091936456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.