Evidence map›Paper›PMID 33117735›Full record

ArticleFrontiers in cellular and infection microbiology2020

Application of Quantitative PCR in the Diagnosis and Evaluating Treatment Efficacy of Leishmaniasis.

Yun Wu, Xiaojun Tian, Nan Song, Minjun Huang, Zhaoyong Wu, Shaogang Li, Nicholas R Waterfield, Bin Zhan, Lei Wang, Guowei Yang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Validation of a Real-Time PCR for the Diagnosis ofTropical medicine and infectious disease · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Precision Medicine in Control of Visceral Leishmaniasis Caused byFrontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Yun WuEmergency and Critical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Xiaojun TianEmergency and Critical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Nan SongEmergency and Critical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Minjun HuangEmergency and Critical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Zhaoyong WuEmergency and Critical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Shaogang LiEmergency and Critical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Nicholas R WaterfieldWarwick Medical School, Warwick University, Coventry, United Kingdom.
Bin ZhanDepartment of Pediatrics and National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, United States.
Lei WangEmergency and Critical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Guowei YangEmergency and Critical Care Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNBaylor College of Medicine · USBeijing Friendship Hospital · CNUniversity of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmaniasis is still a serious neglected tropical disease that may cause death in infected individuals. At present, the clinical diagnosis and treatment monitoring still rely on parasitological culture and microscopy that needs experienced technicians. The low sensitivity and inconvenience of microscopic examination could cause misdiagnosis and relapse of leishmaniasis. There is an urgent need for developing a sensitive and easily operated diagnostic method for the diagnosis and disease management of leishmaniasis. Thus, a quantitative real-time PCR (qPCR) based on the conversed regions of kinetoplast minicircle DNA (mkDNA) of

Indexed as

DNA, KinetoplastLeukocytes, MononuclearDNA, ProtozoanHumansReal-Time Polymerase Chain ReactionSensitivity and SpecificityTreatment OutcomeDNA, KinetoplastDNA, Protozoandiagnosishuman leishmaniasisL. donovaniL. infantumL. majorquantitative PCRtreatment efficacy

Identifiers

PMID33117735
PMCPMC7575730
OpenAlexW3092503236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.