Evidence map›Paper›PMID 33117695›Full record

ReviewFrontiers in oncology2020

The Role of 18F-FDG PET/CT in Guiding Precision Medicine for Invasive Bladder Carcinoma.

Antoine Girard, Helena Vila Reyes, Hiram Shaish, Jean-François Grellier, Laurent Dercle, Pierre-Yves Salaün, Olivier Delcroix, Mathieu Rouanne

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. A pilot study of [European journal of nuclear medicine and molecular imaging · 2025
    Trial
  2. Review
  3. Bladder (San Francisco, Calif.) · 2025
    Article
  4. IsCancers · 2024
    Review
  5. The Added-value of StagingMolecular imaging and radionuclide therapy · 2024
    Article
  6. Review
  7. Initial Experience withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Head-to-head Intra-individual Comparison of [Molecular imaging and biology · 2022
    Article
  13. Review
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Antoine GirardDepartment of Nuclear Medicine, Centre Eugène Marquis, Université Rennes 1, Rennes, France.
Helena Vila ReyesDepartment of Urology, Columbia University Irving Medical Center - New York Presbyterian Hospital, New York, NY, United States.
Hiram ShaishDepartment of Radiology, Columbia University Medical Center, New York, NY, United States.
Jean-François GrellierCentre Cardiologique du Nord, Nuclear Medicine, Saint-Denis, France.
Laurent DercleDepartment of Radiology, New York Presbyterian Hospital - Columbia University Medical Center, New York, NY, United States.
Pierre-Yves SalaünDepartment of Nuclear Medicine, Centre Hospitalier Régional Universitaire de Brest, Brest cedex, France.
Olivier DelcroixDepartment of Nuclear Medicine, Centre Hospitalier Régional Universitaire de Brest, Brest cedex, France.
Mathieu RouanneDepartment of Urology, Hôpital Foch, Université Versailles-Saint-Quentin-en-Yvelines, Université Paris-Saclay, Suresnes, France.
Columbia University Irving Medical Center · USCentre Hospitalier Régional Universitaire de Brest · FRCentre Cardiologique du Nord · FRCentre Eugène Marquis · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer (BC) is the 10th most common cancer worldwide. Approximately one quarter of patients with BC have muscle-invasive disease (MIBC). Muscle-invasive disease carries a poor prognosis and choosing the optimal treatment option is critical to improve patients' outcomes. Ongoing research supports the role of 2-deoxy-2-(18F)fluoro-D-glucose positron emission tomography (18F-FDG PET) in guiding patient-specific management decisions throughout the course of MIBC. As an imaging modality, 18F-FDG PET is acquired simultaneously with either computed tomography (CT) or MRI to offer a hybrid approach combining anatomical and metabolic information that complement each other. At initial staging, 18F-FDG PET/CT enhances the detection of extravesical disease, particularly in patients classified as oligometastatic by conventional imaging. 18F-FDG PET/CT has value in monitoring response to neoadjuvant and systemic chemotherapy, as well as in localizing relapse after treatment. In the new era of immunotherapy, 18F-FDG PET/CT may also be useful to monitor treatment efficacy as well as to detect immune-related adverse events. With the advent of artificial intelligence techniques such as radiomics and deep learning, these hybrid medical images can be mined for quantitative data, providing incremental value over current standard-of-care clinical and biological data. This approach has the potential to produce a major paradigm shift toward data-driven precision medicine with the ultimate goal of personalized medicine. In this review, we highlight current literature reporting the role of 18F-FDG PET in supporting personalized management decisions for patients with MIBC. Specific topics reviewed include the incremental value of 18F-FDG PET in prognostication, pre-operative planning, response assessment, prediction of recurrence, and diagnosing drug toxicity.

Indexed as

bladder cancerimmunotherapymuscle invasive bladder cancerPET – Positron Emission Tomographystaging

Identifiers

PMID33117695
PMCPMC7574640
OpenAlexW3092128963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.