Evidence map›Paper›PMID 33117688›Full record

ArticleFrontiers in oncology2020

LINC01315 Impairs microRNA-211-Dependent DLG3 Downregulation to Inhibit the Development of Oral Squamous Cell Carcinoma.

Fu-Bo Chen, Peng Wu, Rong Zhou, Qi-Xiang Yang, Xu Zhang, Rao-Rao Wang, Sheng-Cai Qi, Xi Yang

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Fu-Bo ChenDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Peng WuDepartment of Othorpaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Rong ZhouDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Qi-Xiang YangDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Xu ZhangDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Rao-Rao WangDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Sheng-Cai QiDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Xi YangDepartment of Oral & Maxillofacial - Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tongji University · CNShanghai Tenth People's Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have revealed that long non-coding RNAs (lncRNAs) involve in the progression of oral squamous cell carcinoma (OSCC). These lncRNAs have emerged as biomarkers or therapeutic targets for OSCC. We here aimed to investigate the role of lncRNA LINC01315 in OSCC and the related mechanisms. LINC01315 and DLG3 were determined to be poorly expressed while microRNA-211 (miR-211) was highly expressed in OSCC tissues and cells using RT-qPCR and western blot analysis. Based on the results obtained from dual-luciferase reporter gene, RIP, and FISH assays, LINC01315 was found to upregulate DLG3 expression by competitively binding to miR-211. Upon altering the expression of LINC01315, and/or miR-211 in OSCC cells with shRNA, mimic, or an inhibitor, we assessed their effects on OSCC cell proliferation, migration, invasion, and apoptosis. LINC01315 knockdown enhanced OSCC cell proliferation, migration and invasion, but dampened their apoptosis, all of which could be reversed by miR-211 inhibition. Elevation of DLG3, a target gene of miR-211, activated the Hippo signaling pathway, whereby suppressing OSCC progression

Indexed as

DLG3Hippo signaling pathwayinvasionLINC01315microRNA-211migrationoral squamous cell carcinomaproliferation

Identifiers

PMID33117688
PMCPMC7549330
OpenAlexW3091202129

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.