Evidence map›Paper›PMID 33117610›Full record

ArticleTranslational vision science & technology2020

Transgenic Expression of

Derek M Waldner, Kenichi Ito, Li-Li Chen, Lisa Nguyen, Robert L Chow, Amy Lee, Derrick E Rancourt, Francois Tremblay, William K Stell, N Torben Bech-Hansen

Open access · goldAbstract read
In one paragraph

Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Aland Island Eye Disease with Retinoschisis in the Clinical Spectrum ofInternational journal of molecular sciences · 2024
    Article
  4. Article
  5. Review
  6. Cav1.4 dysfunction and congenital stationary night blindness type 2.Pflugers Archiv : European journal of physiology · 2021
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Derek M WaldnerGraduate Department of Neuroscience, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Kenichi ItoDepartment of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada.
Li-Li ChenDepartment of Biology, University of Victoria, Victoria, BC, Canada.
Lisa NguyenDepartment of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Robert L ChowDepartment of Biology, University of Victoria, Victoria, BC, Canada.
Amy LeeDepartment of Molecular Physiology and Biophysics, Department of Otolaryngology Head-Neck Surgery and Department of Neurology, University of Iowa, Iowa City, IA, USA.
Derrick E RancourtDepartment of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada.
Francois TremblayDepartment of Ophthalmology and Visual Sciences, Faculty of Medicine, and Clinical Vision Sciences Program, Faculty of Health Dalhousie University, NS, Canada.
William K StellDepartment of Cell Biology and Anatomy and Department of Surgery, Hotchkiss Brain Institute, and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
N Torben Bech-HansenDepartment of Medical Genetics, and Department of Surgery, Alberta Children's Hospital Research Institute, and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
University of Calgary · CAUniversity of Victoria · CAAlberta Children's Hospital · CADalhousie University · CAUniversity of Iowa · US

Funding

Calcium channels in retinal photoreceptorsR01EY026817 · NEI · UNIVERSITY OF TEXAS AT AUSTIN · PI LEE, AMY · 2017 to 2025
$4.4M
6 · The paper itself

Abstract

Purpose: Congenital stationary night blindness 2A (CSNB2A) is a genetic retinal disorder characterized by poor visual acuity, nystagmus, strabismus, and other signs of retinal dysfunction resulting from mutations in Methods: Strategic creation, breeding and use of transgenic mouse lines allowed for Cre-driven retina-specific expression of Results: Mosaic, prenatal expression of Conclusions: This report describes a novel system for Cre-inducible expression of Translational Relevance: These data have relevance in the treatment of CSNB2A and in understanding how photoreceptor integration might be achieved in retinas in which photoreceptors have been lost, such as retinitis pigmentosa, age-related macular degeneration, and other degenerative conditions.

Indexed as

Calcium Channels, L-TypeEye Diseases, HereditaryNight BlindnessAnimalsGenetic Diseases, X-LinkedMiceMice, TransgenicMyopiaRetinaCacna1f protein, mouseCalcium Channels, L-TypeCacna1fcalcium channelsCav1.4channelopathiesCSNB2A

Identifiers

PMID33117610
PMCPMC7571326
OpenAlexW3092698459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.