ArticleEuropean journal of translational myology2020
Sporadic late onset nemaline myopathy with monoclonal gammopathy of undetermined significance: two cases with long term stability.
Article in European journal of translational myology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Clinicopathologic Profiles of Sporadic Late-Onset Nemaline Myopathy: Practical Importance of Anti-α-Actinin Immunostaining.Neurology(R) neuroimmunology & neuroinflammation · 2022Article
- Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review.Frontiers in oncology · 2022Article
- Inflammatory features in sporadic late-onset nemaline myopathy are independent from monoclonal gammopathy.Brain pathology (Zurich, Switzerland) · 2021Article
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5 authors at 1 institution in 1 country.
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Abstract
Monoclonal gammopathy of undetermined significance (MGUS) associated to sporadic late onset nemaline myopathy (SLONM) is a rare and severely disabling condition of quickly progressive limb girdle acquired myopathy. It is believed by some authors to be due to myotoxicity of light chain deposits. Two female patients were diagnosed with MGUS associated SLONM. In the first case, diagnosis was delayed by 6 years thus giving time for a severe generalized myopathy and cardiomyopathy to develop. A single anti-myeloma chemotherapy with lenalidomide markedly improved and stabilized the patient's condition despite respiratory and cardiac insufficiency. In our second patient the condition was identified one year after onset of the first symptom and markedly improved after autologous bone marrow transplantation and lenalidomide. Clinicians should be aware of monoclonal gammopathy associated sporadic late onset nemaline myopathy as this acquired muscle disorder, although extremely rare, may be reversed by adequate management.
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