Evidence map›Paper›PMID 33117415›Full record

ArticleFrontiers in genetics2020

Transcriptomic Analysis Reveals the Involvement of lncRNA-miRNA-mRNA Networks in Hair Follicle Induction in Aohan Fine Wool Sheep Skin.

Ranran Zhao, Jing Li, Nan Liu, Hegang Li, Lirong Liu, Feng Yang, Lanlan Li, Yuan Wang, Jianning He

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. miR-27a TargetingAnimals : an open access journal from MDPI · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ranran ZhaoCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China.
Jing LiQufu Animal Husbandry and Veterinary Technical Service Center, Qufu, China.
Nan LiuCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China.
Hegang LiCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China.
Lirong LiuChina Animal Health and Epidemiology Center, Qingdao, China.
Feng YangCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot, China.
Lanlan LiCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China.
Yuan WangCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China.
Jianning HeCollege of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China.
Qingdao Agricultural University · CNChina Animal Health and Epidemiology Center · CNInner Mongolia Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNA) and microRNAs (miRNA) are new found classes of non-coding RNAs (ncRNAs) that are not translated into proteins but regulate various cellular and biological processes. In this study, we conducted a transcriptomic analysis of ncRNA and mRNA expression in Aohan fine wool sheep (AFWS) at different growth stages (embryonic day 90, embryonic day 120, and the day of birth), and explored their relationship with wool follicle growth. In total, 461 lncRNAs, 106 miRNAs, and 1,009 mRNAs were found to be differentially expressed during the three stages of wool follicle development. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to clarify the roles of the differentially expressed lncRNA, miRNA, and mRNA in the different stages of wool follicle development. Quantitative real-time PCR (qRT-PCR) was used to validate the results of RNA-seq analysis. lncRNA (MSTRG.223165) was found to act as a competing endogenous RNA (ceRNA) and may participate in wool follicle development by acting as an miR-21 sponge. Network prediction implicated the MSTRG.223165-miR-21-

Indexed as

Aohan fine wool sheeplong non-coding RNAmicroRNAmRNAskin developmentwool follicle

Identifiers

PMID33117415
PMCPMC7528302
OpenAlexW3027167263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.