Evidence map›Paper›PMID 33117399›Full record

ArticleFrontiers in immunology2020

Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation and Immunity.

Min Xu, Wei Yang, Xuanchuan Wang, Deepak Kumar Nayak

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  6. Unraveling the Causal Linkages ofBioMed research international · 2026
    Article
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  9. Upper Respiratory Microbiome in Vasculitis.Rheumatic diseases clinics of North America · 2025
    Review
  10. SCGB1A1 as a Key Regulator of Splenic Immune Dysfunction in COPD: Insights From a Murine Model.International journal of chronic obstructive pulmonary disease · 2025
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Min XuDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
Wei YangDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, United States.
Xuanchuan WangDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Deepak Kumar NayakInterdisciplinary Oncology, University of Arizona College of Medicine, Phoenix, AZ, United States.
Washington University in St. Louis · USUniversity of Arizona · USZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alveolar macrophage (AM) is a mononuclear phagocyte key to the defense against respiratory infections. To understand AM's role in airway disease development, we examined the influence of Secretoglobin family 1a member 1 (SCGB1A1), a pulmonary surfactant protein, on AM development and function. In a murine model, high-throughput RNA-sequencing and gene expression analyses were performed on purified AMs isolated from mice lacking in

Indexed as

AnimalsChemokinesCytokinesDown-RegulationGene ExpressionInflammationLungMacrophages, AlveolarMiceMice, Inbred C57BLMice, KnockoutSignal TransductionUp-RegulationUteroglobinChemokinesCytokinesScgb1a1 protein, mouseUteroglobinalveolar macrophageClara cell secretory proteinclub cellcytokine stormlung surfactantSCGB1A1

Identifiers

PMID33117399
PMCPMC7558713
OpenAlexW3089938205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.