Evidence map›Paper›PMID 33117344›Full record

ArticleFrontiers in immunology2020

Retinoid Signaling in Intestinal Epithelial Cells Is Essential for Early Survival From Gastrointestinal Infection.

Lindsay M Snyder, Juhi Arora, Mary J Kennett, Veronika Weaver, Margherita T Cantorna

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Significance of Vitamins A and E in Cancer Progression and Prevention.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Gut Health and Influencing Factors in Pigs.Animals : an open access journal from MDPI · 2023
    Review
  9. Article
  10. β-carotene improves fecal dysbiosis and intestinal dysfunctions in a mouse model of vitamin A deficiency.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lindsay M SnyderDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Juhi AroraDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Mary J KennettDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Veronika WeaverDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Margherita T CantornaDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Pennsylvania State University · US

Funding

Vitamin D Fluctuations and the Mucosal Immune ResponseR01AT005378 · NCCIH · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T · 2009 to 2020
$4.1M
Research Training in Physiological Adaptations to StressT32GM108563 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, KORZICK, DONNA HOPE · 2014 to 2023
$2.2M
Vitamin A mediated protection from gastrointestinal infectionR56AI114972 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, ROSS, A. CATHARINE · 2015 to 2015
$477k
NCCIH NIH HHS R01 AT005378NIAID NIH HHS R56 AI114972NIGMS NIH HHS T32 GM108563
6 · The paper itself

Abstract

Vitamin A deficiency (A-) increases morbidity and mortality to gastrointestinal (GI) infection. Blocking retinoid signaling (dominant negative retinoic acid receptor, dnRAR) in intestinal epithelial cells (IEC,

Indexed as

Signal TransductionAnimalsBiomarkersCitrobacter rodentiumColitisDextran SulfateDisease Models, AnimalDisease SusceptibilityEnterobacteriaceae InfectionsIntestinal MucosaMiceMice, KnockoutPrognosisReceptors, Retinoic AcidRetinoidsSeverity of Illness IndexBiomarkersDextran SulfateReceptors, Retinoic AcidRetinoidsbarriergastrointestinal tractinfectionretinoic acid receptorvitamin A deficiency

Identifiers

PMID33117344
PMCPMC7578243
OpenAlexW3085267832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.