Evidence map›Paper›PMID 33117343›Full record

ArticleFrontiers in immunology2020

Azithromycin Differentially Alters TCR-Activated Helper T Cell Subset Phenotype and Effector Function.

Abdul Wahid Ansari, Fatemeh Saheb Sharif-Askari, Manju Nidagodu Jayakumar, Abdul Khader Mohammed, Narjes Saheb Sharif-Askari, Thenmozhi Venkatachalam, Bassam Mahboub, Reinhold E Schmidt, Rifat Akram Hamoudi, Rabih Halwani and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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  3. Immunity AgainstVaccines · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 5 countries.

Abdul Wahid AnsariSharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Fatemeh Saheb Sharif-AskariSharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Manju Nidagodu JayakumarSharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Abdul Khader MohammedSharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Narjes Saheb Sharif-AskariSharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Thenmozhi VenkatachalamSharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Bassam MahboubDepartment of Pulmonary Medicine, Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates.
Reinhold E SchmidtDepartment of Clinical Immunology and Rheumatology, Hannover Medical School, Hanover, Germany.
Rifat Akram HamoudiSharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Rabih HalwaniDepartment of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Qutayba HamidDepartment of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
University of Sharjah · AEKing Saud University · SAMcGill University · CAMedizinische Hochschule Hannover · DERashid Hospital · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In addition to their antibiotic activities, azithromycin (AZM) exhibits anti-inflammatory effects in various respiratory diseases. One of the potent anti-inflammatory mechanisms is through inhibition of CD4+ helper T (Th) cell effector function. However, their impact on specific Th subset is obscure. Herein, we demonstrate the cellular basis of phenotypic and functional alterations associated with Th subsets following AZM treatment

Indexed as

Anti-Bacterial AgentsAzithromycinBacterial InfectionsCell DifferentiationCell MovementCells, CulturedHealthy VolunteersHumansInterferon-gammaInterleukin-4Receptors, Antigen, T-CellReceptors, CCR4Receptors, CXCR3Th1 CellsT-Lymphocyte SubsetsAnti-Bacterial AgentsAzithromycinCCR4 protein, humanCXCR3 protein, humanInterferon-gammaInterleukin-4Receptors, Antigen, T-CellReceptors, CCR4Receptors, CXCR3anti-inflammatoryapoptosisazithromycinCCR4CD4+ helper T cellsCXCR3IFN-γIL-4

Identifiers

PMID33117343
PMCPMC7575909
OpenAlexW3089983256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.