ArticleFrontiers in immunology2020
Mast Cells in Skin Scarring: A Review of Animal and Human Research.
Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Study on the Potential Molecular Mechanism of Keloid Disease Associated With Single Cell Combined Mendelian Randomization.Journal of cosmetic dermatology · 2026Article
- Mast cell driven immunometabolism as a therapeutic entry point in ESCC.Frontiers in cell and developmental biology · 2026Review
- Mendelian randomization analysis of the causal relationship between immune cells and keloid.Dermatology reports · 2025Article
- Systemic effects of oral tolerance improve the healing of several and concomitant wounds on different parts of the body.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- LangerinClinical, cosmetic and investigational dermatology · 2025Review
- The Presence and Severity of Inferior Turbinate Hypertrophy in Patients with Hypertrophic Scars.Sisli Etfal Hastanesi tip bulteni · 2024Article
- Acne-induced pathological scars: pathophysiology and current treatments.Burns & trauma · 2024Review
- Scars.Nature reviews. Disease primers · 2023Review
- Defining a Unique Gene Expression Profile in Mature and Developing Keloids.JID innovations : skin science from molecules to population health · 2023Article
- Tissue RNA Sequencing Reveals Novel Biomarkers Associated with Postoperative Keloid Recurrence.Journal of clinical medicine · 2023Article
- Mechanisms underlying pathological scarring by fibroblasts during wound healing.International wound journal · 2023Article
- Xenogeneic mesenchymal stem cell biocurative improves skin wounds healing in diabetic mice by increasing mast cells and the regenerative profile.Regenerative therapy · 2023Article
- Mast cell-mediated immune regulation in health and disease.Frontiers in medicine · 2023Review
- Skin immunity in wound healing and cancer.Frontiers in immunology · 2023Review
- Advances in Immunomodulatory Mechanisms of Mesenchymal Stem Cells-Derived Exosome on Immune Cells in Scar Formation.International journal of nanomedicine · 2023Review
- An updated review of the immunological mechanisms of keloid scars.Frontiers in immunology · 2023Review
- Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.International journal of molecular sciences · 2022Article
- Review
- Recognizing Drug Hypersensitivity in Pigmented Skin.Immunology and allergy clinics of North America · 2022Review
- Evaluation of a Gel Containing aInternational journal of molecular sciences · 2022Article
Corrections and comments
- Retraction · 2025-10-15Duplication of/in Image · Euphemisms for Duplication · Investigation by Journal/Publisher · Investigation by Third Party · Unreliable Data · Unreliable Results and/or Conclusions · · See also: https://pubpeer.com/publications/C387FCF84889570C7389937A0CD422
- Retracted
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
Mast cells (MCs) are an important immune cell type in the skin and play an active role during wound healing. MCs produce mediators that can enhance acute inflammation, stimulate re-epithelialisation as well as angiogenesis, and promote skin scarring. There is also a link between MCs and abnormal pathological cutaneous scarring, with increased numbers of MCs found in hypertrophic scars and keloid disease. However, there has been conflicting data regarding the specific role of MCs in scar formation in both animal and human studies. Whilst animal studies have proved to be valuable in studying the MC phenomenon in wound healing, the appropriate translation of these findings to cutaneous wound healing and scar formation in human subjects remains crucial to elucidate the role of these cells and target treatment effectively. Therefore, this perspective paper will focus on evaluation of the current evidence for the role of MCs in skin scarring in both animals and humans in order to identify common themes and future areas for translational research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.