ArticleFrontiers in endocrinology2020
The Role of Estrogen in Anxiety-Like Behavior and Memory of Middle-Aged Female Rats.
Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Determinants of academic achievement among higher education student found in low resource setting, A systematic review.PloS one · 2023Pooled it
- Conserved trajectories of age-related thigmotaxis across insects and mammals reveal the house cricket as a scalable model for behavioral aging.GeroScience · 2026Article
- Preoperative dental anxiety across menstrual cycle phases in women undergoing root canal treatment.Scientific reports · 2025Article
- The effects of pharmacologic estradiol on anxiety-related behavior in adolescent and adult female mice.Physiology & behavior · 2025Article
- Sex, senescence, senolytics, and cognition.Frontiers in aging neuroscience · 2025Review
- Comparing the effect of plasma therapy with estradiol valerate in motor and cognitive behavioral disorders in ovariectomized old rats: Behavioral, biochemical, and protein expression.Iranian journal of basic medical sciences · 2025Article
- Chronic 17β-estradiol treatment improves negative valence, anhedonic profile, and social interactions in ovariectomized, middle-aged female rats.Frontiers in behavioral neuroscience · 2025Article
- Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice.Nature communications · 2024Article
- Article
- Mechanisms of microbiota-gut-brain axis communication in anxiety disorders.Frontiers in neuroscience · 2024Review
- Subchronic Arsenic Exposure Induces Behavioral Impairments and Hippocampal Damage in Rats.Toxics · 2023Article
- Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice.Scientific reports · 2023Article
- Sex Differences in Behavior and Learning Abilities in Adult Rats.Life (Basel, Switzerland) · 2023Article
- Prepubertal ovariectomy confers resilience to stress-induced anxiety in adult female mice.Psychoneuroendocrinology · 2023Article
- Differences in learning and memory between middle-aged female and male rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Structural, functional, and behavioral significance of sex and gonadal hormones in the basolateral amygdala: A review of preclinical literature.Alcohol (Fayetteville, N.Y.) · 2022Review
- Cigarette smoke and nicotine effects on behavior in HIV transgenic rats.Behavioural brain research · 2022Article
- Estrogen receptors mediate the antidepressant effects of aerobic exercise: A possible new mechanism.Frontiers in aging neuroscience · 2022Article
- Estrogen, Cognitive Performance, and Functional Imaging Studies: What Are We Missing About Neuroprotection?Frontiers in cellular neuroscience · 2022Review
- Behavioral, Oxidative, and Biochemical Effects of Omega-3 on an Ovariectomized Rat Model of Menopause.Journal of menopausal medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging in women is associated with low estrogen, but also with cognitive decline and affective disorders. Whether low estrogen is causally responsible for these behavioral symptoms is not clear. Thus, we aimed to examine the role of estradiol in anxiety-like behavior and memory in rats at middle age. Twelve-month old female rats underwent ovariectomy (OVX) or were treated with 1 mg/kg of letrozole-an aromatase inhibitor. In half of the OVX females, 10 μg/kg of 17β-estradiol was supplemented daily for 4 weeks. Vehicle-treated sham-operated and OVX females served as controls. For behavioral assessment open field, elevated plus maze and novel object recognition tests were performed. Interaction between ovarian condition and additional treatment had the main effect on anxiety-like behavior of rats in the open field test. In comparison to control females, OVX females entered less frequently into the center zone of the open field (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.