Evidence map›Paper›PMID 33117282›Full record

ArticleFrontiers in endocrinology2020

Euthyroid Sick Syndrome in Patients With COVID-19.

Runmei Zou, Chenfang Wu, Siye Zhang, Guyi Wang, Quan Zhang, Bo Yu, Ying Wu, Haiyun Dong, Guobao Wu, Shangjie Wu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 8 pooled it
2.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 8 syntheses or guidelines pooled it, 117 citations in OpenAlex.

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  16. Low T3 syndrome as a predictor of poor prognosis in peripheral T-cell lymphomas.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Runmei ZouChildren's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Chenfang WuCritical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Siye ZhangCritical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Guyi WangCritical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Quan ZhangCritical Care Medicine, The First Hospital of Changsha, Changsha, China.
Bo YuCritical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Ying WuCritical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Haiyun DongCritical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Guobao WuCritical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Shangjie WuDepartment of Respiratory, The Second Xiangya Hospital, Central South University, Changsha, China.
Yanjun ZhongCritical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CNThe First Hospital of Changsha · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Coronavirus disease 2019 (COVID-19) has been shown to affect almost every organ throughout the body. However, it is not clear whether the thyroid gland is impaired in COVID-19 patients. Euthyroid sick syndrome (ESS) is usually associated with the disease severity and deterioration prognosis in critical illness. In this study, the thyroid function of COVID-19 patients was assessed and factors associated with outcomes were analyzed to determine the potential predictive value of ESS. Methods: Clinical and laboratory data of COVID-19 patients with or without ESS in Changsha, China, were collected and analyzed on admission. Kaplan-Meier curve and cox regression model were utilized to determine the correlation between ESS and the endpoints. Subsequently, a receiver operating characteristic (ROC) curve was plotted to evaluate the predictive performances of FT3 and C-reactive protein (CRP) in the disease severity. Results: Forty-one (27.52%) cases of COVID-19 patients diagnosed with ESS. ESS patients had higher proportions of fever, shortness of breath, hypertension, diabetes, and severe events than those of non-ESS patients. The levels of erythrocyte sedimentation rate and C-reactive protein, and the positive rate of procalcitonin were significantly higher, whereas the lymphocyte count was apparently lower in ESS patients than in non-ESS patients. The regression analysis showed that ESS was significantly associated with the disease severity of COVID-19 (HR = 2.515, 95% CI: 1.050-6.026, Conclusion: ESS was significantly associated with the disease severity and inflammatory parameters in COVID-19 patients.

Indexed as

Severity of Illness IndexAdultAgedAged, 80 and overBetacoronavirusChinaCoronavirus InfectionsCOVID-19Euthyroid Sick SyndromesFemaleHumansMaleMiddle AgedPandemicsPneumonia, ViralPrognosisCoronavirus Disease 2019 (COVID-19)C-reactive proteindisease severityeuthyroid sick syndromethyroid function

Identifiers

PMID33117282
PMCPMC7575767
OpenAlexW3092182435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.