ArticleFrontiers in endocrinology2020
Preterm Birth in Assisted Reproductive Technology: An Analysis of More Than 20,000 Singleton Newborns.
Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- The risk of congenital malformations and neonatal outcomes among singletons and twins born after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and Bayesian network meta-regression analysis.BMC pregnancy and childbirth · 2026Pooled it
- Obstetric and neonatal outcomes after natural versus artificial cycle frozen embryo transfer and the role of luteal phase support: a systematic review and meta-analysis.Human reproduction update · 2023Pooled it
- Recent advances in sex-specific reproductive microphysiological systems for the systematic evaluation of assisted reproductive technology.Materials today. Bio · 2026Review
- An interpretable machine learning model for predicting NICU admission in preterm infants: a single-center retrospective cohort study.Translational pediatrics · 2026Article
- Association betweenFrontiers in endocrinology · 2026Observational
- A prediction model of preterm birth in singleton pregnancy after assisted reproduction therapy.BMC pregnancy and childbirth · 2025Article
- Associations of maternal PM2.5 exposure with preterm birth and miscarriage in women undergoingFrontiers in endocrinology · 2025Article
- Predicting preterm birth using electronic medical records from multiple prenatal visits.BMC pregnancy and childbirth · 2024Article
- Article
- Risk Factors for Prematurity and Congenital Malformations in Assisted Reproductive Technology Pregnancies-A Retrospective Study.Journal of clinical medicine · 2024Article
- Body mass index impacts ectopic pregnancy during in vitro fertilization: an analysis of 42,362 clinical pregnancy cycles.Reproductive biology and endocrinology : RB&E · 2023Article
- The risk of prematurity in Cameroonian children born after in vitro fertilisation.Ghana medical journal · 2023Article
- Nomogram for predicting the risk of preterm birth in women undergoing in vitro fertilization cycles.BMC pregnancy and childbirth · 2023Article
- Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety.Fertility and sterility · 2023Article
- Nomogram for predicting the risk of preterm delivery after IVF/ICSI treatment: an analysis of 11513 singleton births.Frontiers in endocrinology · 2023Article
- The use of IVF/ICSI and risk of postpartum hemorrhage: A retrospective cohort study of 153,765 women in China.Frontiers in public health · 2023Article
- Effect of artificial cycle with or without GnRH-a pretreatment on pregnancy and neonatal outcomes in women with PCOS after frozen embryo transfer: a propensity score matching study.Reproductive biology and endocrinology : RB&E · 2022Article
- Analysis of Risk Factors Affecting Cumulative Live Birth in Couples With Unexplained Infertility Undergoing IVF/ICSI.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Several studies have shown that newborns conceived through the ART procedures were associated with an increased incidence of preterm delivery compared to those conceived spontaneously regardless of the type of ART procedure. The aim of the study was to explore risk factors for preterm birth (PTB) in assisted reproductive technology. Method: In this single center retrospective cohort study, a total of 23,111 singleton newborns from January 2010 to December 2018 were included. The primary outcome in this study was preterm birth, defined as live birth before 37 weeks' gestation. Result: In the 23,111 pregnancies, the incidence of PTB was 7.13%. In multivariate logistic regression analysis model, BMI was an independent predictor for PTB (OR = 1.05, 95% CI: 1.03-1.07; P = 0.00 in IVF/ICSI cycles; OR = 1.08, 95% CI: 1.03-1.12; P = 0.00 in IUI cycles). Also, another independent predictor in ART was male newborns (OR = 1.27, 95% CI: 1.14-1.41; P = 0.00 in IVF/ICSI cycles; OR = 1.60, 95% CI: 1.17-2.18; P = 0.00 in IUI cycles). In IVF/ICSI cycles, PTB was significantly higher in patients with advanced age (9.56% in ≥ 38 years old), and in patients with a history of cesarean section (10.39%). In addition, Blastocyst transfer, and frozen thawed transfer were also risk factor for PTB as compared with cleavage transfer, and fresh transfer, respectively. Moreover, in frozen thawed transfer cycles, stimulated protocol (estrogen-progesterone) increased PTB as compared with natural protocol (OR = 1.33, 95% CI: 1.12-1.59; P = 0.00). This situation was similar in IUI cycles as stimulated protocol also increased PTB when compared with natural protocol (OR = 1.72, 95% CI: 1.19-2.48; P = 0.00). Conclusion: Body mass index (BMI), delivery with male newborn, as well as stimulated protocols, were independent risk factors for PTB in both IVF/ICSI and IUI treatment cycles. In IVF/ICSI cycles, independent risk factors also included maternal, history of cesarean section, frozen thawed transfer, and blastocyst transfer.
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Registered trials
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