ArticleFrontiers in aging neuroscience2020
Pilot Investigation: Older Adults With Atrial Fibrillation Demonstrate Greater Brain Leukoaraiosis in Infracortical and Deep Regions Relative to Non-Atrial Fibrillation Peers.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Atrial Fibrillation, Cerebral Small Vessel Disease and Gender Medicine: Focus on Biomarkers and Neuroimaging.Journal of clinical medicine · 2026Article
- Distinct spatiotemporal patterns of white matter hyperintensity progression.Nature communications · 2025Article
- Association Between the Circadian Rhythm of Arterial Blood Pressure and White Matter Lesions in Hospitalized Hypertensive Patients: A Cross-Sectional Study.International journal of general medicine · 2025Article
- White Matter Lesions Predominantly Located in Deep White Matter Represent Embolic Etiology Rather Than Small Vessel Disease.Dementia and neurocognitive disorders · 2023Article
- Preoperative cognition predicts clinical stroke/TIA and mortality after surgical aortic valve replacement in older adults.Journal of clinical and experimental neuropsychology · 2022Article
- Research progress in atrial fibrillation with cerebral small vessel disease.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Relationships between cerebral small vessel diseases markers and cognitive performance in stroke-free patients with atrial fibrillation.Frontiers in aging neuroscience · 2022Article
- Association of White Matter Hyperintensity Markers on MRI and Long-term Risk of Mortality and Ischemic Stroke: The SMART-MR Study.Neurology · 2021Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThis pilot study explored differences in distribution of white matter hyperintensities (called leukoaraiosis; LA) in older adults (mean age = 67 years) with atrial fibrillation (AF) vs. non-AF peers measured by: (1) depth distribution; (2) anterior-posterior distribution; (3) associations between LA and cortical thickness; and (4) presence of lacunae and stroke.
methodsParticipant data (AF
resultsRelative to non-AF peers, the AF group had twice the total LA volume (AF = 2.1% vs. Non-AF = 0.9%), over 10 times greater infracortical LA (AF = 0.72% vs. Non-AF = 0.07%), and three times greater deep LA (AF = 2.1% vs. Non-AF = 0.6%). Examinations of the extent of LA in anterior vs. posterior regions revealed a trend for more posterior relative to anterior LA. In the entire sample, total LA and infracortical LA were negatively associated with temporal lobe thickness. Only those with AF presented with lacunae or stroke.
conclusionAging adults with AF had more total white matter disease than those without AF, particularly near the cortical mantle and deep within the cortex. Total and infracortical white matter disease in the entire sample negatively associated with temporal lobe thickness. Results suggest that those with AF have a distinct pattern of LA relative to those without AF, and that LA severity for all individuals may associate with structural changes in the cortex.
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