Evidence map›Paper›PMID 33116918›Full record

ArticleHIV/AIDS (Auckland, N.Z.)2020

Prevalence and Predictors of Neurocognitive Impairment in Ethiopian Population Living with HIV.

Mohammed Salahuddin, Md Dilshad Manzar, Hamid Yimam Hassen, Aleem Unissa, Unaise Abdul Hameed, David Warren Spence, Seithikurippu R Pandi-Perumal

Open access · goldAbstract read
In one paragraph

Article in HIV/AIDS (Auckland, N.Z.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 6 countries.

Mohammed SalahuddinDepartment of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University (Mizan Campus), Mizan, Ethiopia.ORCID 0000-0001-7306-5989
Md Dilshad ManzarDepartment of Nursing, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia.ORCID 0000-0002-5571-3310
Hamid Yimam HassenDepartment of Public Health, College of Health Sciences, Mizan Tepi University, (Mizan Campus), Mizan, Ethiopia.ORCID 0000-0001-6485-4193
Aleem UnissaMalla Reddy College of Pharmacy, Hyderabad, Telangana, India.
Unaise Abdul HameedDepartment of Physiotherapy, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia.ORCID 0000-0002-6689-9958
David Warren SpenceIndependent Researcher, Toronto, ON M6K 2B4, Canada.ORCID 0000-0002-1664-6960
Seithikurippu R Pandi-PerumalSomnogen Canada Inc, Toronto, ON, Canada.ORCID 0000-0002-8686-7259
G Pulla Reddy Dental College & Hospital · INMajmaah University · SAMizan Tepi University · ETMonash University · AUUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundModern antiretroviral therapy has extended the life expectancies of people living with HIV; however, the prevention and treatment of their associated neurocognitive decline have remained a challenge. Consequently, it is desirable to investigate the prevalence and predictors of neurocognitive impairment to help in targeted screening and disease prevention. MATERIALS AND

methodsTwo hundred and forty-four people living with HIV were interviewed in a study using a cross-sectional design and the International HIV Dementia Scale (IHDS). Additionally, the sociodemographic, clinical, and psychosocial characteristics of the patients were recorded. Chi-square and binary logistic regression analysis were used to determine the level of significance among the independent risk factors and probable neurocognitive impairment.

resultsThe point prevalence of neurocognitive impairment was found to be 39.3%. Participants' characteristics of being older than 40 years (AOR= 2.81 (95% CI; 1.11-7.15)), having a history of recreational drug use (AOR= 13.67 (95% CI; 6.42-29.13)), and being non-compliant with prescribed medications (AOR= 2.99 (95% CI; 1.01-8.87)) were independent risk factors for neurocognitive impairment.

conclusionThe identification of predictors, in the Ethiopian people living with HIV, may help in the targeted screening of vulnerable groups during cART follow-up visits. This may greatly help in strategizing and implementation of the prevention program, more so, because (i) HIV-associated neurocognitive impairment is an asymptomatic condition for considerable durations, and (ii) clinical trials on neurocognitive impairment therapies have been unsuccessful.

Indexed as

AfricacARTdementiaEthiopiaHIVIHDSrecreational drugs

Identifiers

PMID33116918
PMCPMC7568595
OpenAlexW3092401758

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.