ArticleCancer management and research2020
Combination of Hematology Indicators and Oncological Characteristics as a New Promising Prognostic Factor in Localized Clear Cell Renal Cell Carcinoma.
Article in Cancer management and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Pseudocapsule thickness is positively associated with prognosis in patients with clear cell renal cell carcinoma.BMC cancer · 2025Article
- Development and validation of intravoxel incoherent motion diffusion weighted imaging-based model for preoperative distinguishing nuclear grade and survival of clear cell renal cell carcinoma complicated with venous tumor thrombus.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Identification of key genes of the ccRCC subtype with poor prognosis.Scientific reports · 2022Article
- The Role of C-Reactive Protein in Kidney, Bladder, and Prostate Cancers.Frontiers in immunology · 2021Review
- A novel nomogram can predict pathological T3a upstaged from clinical T1a in localized renal cell carcinoma.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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Authors and funding
12 authors.
Funding
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Abstract
purposeThis study aimed to construct a predictive model for recurrence and metastasis in patients with localized clear cell renal cell carcinoma (ccRCC) based on multiple preoperative blood indexes and oncological characteristics. PATIENTS AND
methodsOverall, 442 patients with localized ccRCC between 2013 and 2015 were included. Using least absolute shrinkage and selection operator (LASSO) Cox regression analysis, the top three risk factors from the peripheral blood indicators were screened to construct a risk score, and a prognostic model was established. Harrell's concordance index (C-index) was applied to evaluate the predictive accuracy of the model for predicting disease-free survival (DFS) in ccRCC.
resultsOut of 38 blood indexes, the top three predictors were fibrinogen (FIB), C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR). The FIB-CRP-NLR (FCN) score (hazard ratio [HR]: 1.86, 95% confidence interval [CI]: 1.21-2.9,
conclusionThe FCN score combining peripheral blood indicators of inflammation and coagulation is an independent prognostic marker of ccRCC. The FCNTG model, which systemically incorporates preoperative blood indexes to oncological characteristics, shows its advantages of convenience and high prediction efficiency.
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