Evidence map›Paper›PMID 33116743›Full record

ArticleClinical and experimental gastroenterology2020

No Significant Effect of Daikenchuto (TJ-100) on Peritoneal IL-9 and IFN-γ Levels After Pancreaticoduodenectomy.

Hiromichi Maeda, Ken-Ichi Okada, Tsutomu Fujii, Mari S Oba, Manabu Kawai, Seiko Hirono, Yasuhiro Kodera, Masayuki Sho, Takahiro Akahori, Yasuhiro Shimizu and 8 more

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Article in Clinical and experimental gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 1 country.

Hiromichi Maeda *Department of Surgery, Kochi Medical School, Nankoku, Kochi 780-8505, Japan.
Ken-Ichi Okada *Second Department of Surgery, Wakayama Medical University, Wakayama 641-8510, Japan.
Tsutomu FujiiDepartment of Surgery and Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
Mari S ObaDepartment of Medical Statistics Faculty of Medicine, Toho University, Ota-ku, Tokyo 143-8540, Japan.
Manabu KawaiSecond Department of Surgery, Wakayama Medical University, Wakayama 641-8510, Japan.
Seiko HironoSecond Department of Surgery, Wakayama Medical University, Wakayama 641-8510, Japan.
Yasuhiro KoderaDepartment of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8560, Japan.
Masayuki ShoDepartment of Surgery, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Takahiro AkahoriDepartment of Surgery, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Yasuhiro ShimizuDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan.
Yoshiyasu AmboDepartment of Surgery, Teine-Keijinkai Hospital, Sapporo, Hokkaido 006-8555, Japan.
Naru KondoDepartment of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
Yoshiaki MurakamiDepartment of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
Jiro OhuchidaDepartment of Surgery, Miyazaki Prefectural Miyazaki Hospital, Miyazaki 889-1692, Japan.
Hidetoshi EguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Hiroaki NaganoDepartment of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan.
Junichi SakamotoTokai Central Hospital, Kakamigahara, Gifu 504-8601, Japan.ORCID 0000-0002-9675-512X
Hiroki YamaueSecond Department of Surgery, Wakayama Medical University, Wakayama 641-8510, Japan.
Wakayama Medical University · JPHiroshima University · JPNara Medical University · JPAichi Cancer Center · JPKōchi University · JPMiyazaki Prefectural Hospital · JPNagoya University · JPTeine Keijinkai Hospital · JPThe University of Osaka · JPToho University · JPTokai Central Hospital · JPUniversity of Toyama · JPYamaguchi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIM AND

backgroundTJ-100 is a traditional Japanese medicine that affects inflammation and gastrointestinal motility, and is used as a preventive and treatment for paralytic ileus. This study aims at determining the effect of TJ-100 on the peritoneal levels of IFN-γ/IL-9, cytokines related to ileus, after pancreaticoduodenectomy (PD) in a clinical setting.

methodsThis was a subsidiary study of the clinical trial investigating the effect of TJ-100 on postoperative bowel function. Ascites was collected from 180 patients using an abdominal drainage tube on postoperative day 1 and 3 after PD (POD 1 or POD 3) and used to measure 27 cytokines. We performed univariate and multivariate analyses using several perioperative variables and administration of TJ-100/placebo to determine the effect of TJ-100 on the levels of IFN-γ and IL-9.

resultsPeritoneal levels of IL-9 and IFN-γ decreased between POD 1 and 3 (Wilcoxon signed-rank test p<0.001). Multivariate analysis was performed after univariate analysis to select the variables and patients with a body mass index of ≥22 kg/m

conclusionTJ-100 did not affect peritoneal IL-9 and IFN-γ levels after PD. This was in accordance with published clinical findings showing no improvement in bowel function after PD and TJ-100 treatment.

Indexed as

Daikenchutoherbal medicineKampopancreatic cancerTNF

Identifiers

PMID33116743
PMCPMC7585168
OpenAlexW3093461704

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.