Evidence map›Paper›PMID 33116687›Full record

ReviewInfection and drug resistance2020

Barriers and Strategies: A Review of Access to Affordable Multi-Drug Resistant Tuberculosis Medication in China.

Yuou Zhang, Xuan Liu, Linghe Yang, Guifang Zhang, Zhaoru Gu, Zhongdan Chen, Jing Sun

Open access · goldAbstract readReview
In one paragraph

Review in Infection and drug resistance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Beta-lactam combination treatment overcomes rifampicin resistance in Mycobacterium tuberculosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Tuberculosis challenges: Resistance, co-infection, diagnosis, and treatment.European journal of microbiology & immunology · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yuou ZhangSchool of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Xuan LiuSchool of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Linghe YangSchool of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Guifang ZhangInstitute of Geriatrics, Beijing Hospital, Beijing, People's Republic of China.
Zhaoru GuInstitute of Cancer, Cancer Hospital Chinese Academy of Medical Sciences, Beijing, People's Republic of China.ORCID 0000-0002-7159-6345
Zhongdan ChenHepatitis/TB/HIV/STI, World Health Organization, Office of the WHO Representative in China, Beijing, People's Republic of China.
Jing SunSchool of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.ORCID 0000-0002-4646-1174
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing Geriatric Hospital · CN

Funding

World Health Organization 001
6 · The paper itself

Abstract

This study analyzed the barriers of patient access to affordable MDR-TB medication in China and the reasons behind, and proposed strategies towards removing the barriers based on literature review and key informant interviews. Reasons behind the high financial burden of MDR-TB patients in China are the lack of a coordinated and multi-sourced financing model to secure patients' access to the expensive novel medicines, and the absence of the safety-net for the patients with low ability to pay the costs. Appropriate health insurance benefit packages and provider payment mechanisms, supportive legal framework, coordinated policies as well as incentives for off-label use of evidence-based repurposed medicines are missing. The observations identified key intervention areas including continued efforts to make the novel effective medicines affordable and to strengthen the legislative protection for off-label use of evidence-based medicines; increase incentives for pharmaceutical companies to expand indications of established medicines based on the evidence; implement public initiatives to support the use of repurposed medicines for diseases with major public health significance, and scale up good practices from local pilots to create a coordinated multi-sourced financing model. A comprehensive approach to address the barriers in the full treatment course of MDR-TB and a safety-net for low-ability-to-pay patients are also critical to secure universal access to affordable MDR-TB medication.

Indexed as

affordablefinancingMDR-TBmedicationoff-label userepurposed medicinessafety-net

Identifiers

PMID33116687
PMCPMC7585516
OpenAlexW3093311569

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.