ArticleInfection and drug resistance2020
Optimized Production of the Allylamine Antifungal "Terbinafine" by
Article in Infection and drug resistance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Probiotic characterization and spore production optimization of Lysinibacillus sp. MK212927.Applied microbiology and biotechnology · 2026Article
- Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis.Applied microbiology and biotechnology · 2024Article
- Identification, Characterization, and Production Optimization of 6-Methoxy-1H-Indole-2-Carboxylic Acid Antifungal Metabolite Produced byMicroorganisms · 2023Article
- New Insights on Biological Activities, Chemical Compositions, and Classifications of Marine Actinomycetes Antifouling Agents.Microorganisms · 2023Review
- Statistical optimization of a podoviral anti-MRSA phage CCASU-L10 generated from an under sampled repository: Chicken rinse.Frontiers in cellular and infection microbiology · 2023Article
- An Anti-MRSA Phage From Raw Fish Rinse: Stability Evaluation and Production Optimization.Frontiers in cellular and infection microbiology · 2022Article
- Article
- Exploring the Nature of the Antimicrobial Metabolites Produced byAntibiotics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe aimed to optimize the factors affecting the production of the allylamine antifungal, terbinafine, by
methodsWe employed a central composite design to optimize the five most important variables influencing the production of terbinafine which were carbon source, nitrogen source, temperature, pH and agitation.
resultsThe optimum conditions were found to be starch 5 g/L, ammonium chloride 5 g/L, temperature 32°C, agitation 150 rpm and pH 7. The actual response (inhibition zone diameter) was highly comparable to the value predicted by the model, indicating a valid model. Using the standard calibration curve of terbinafine, the optimized conditions resulted in an increase in the antifungal metabolite production (terbinafine) by about 1.6-fold (1814.662 µg/mL compared to 1165.550 µg/mL under standardized conditions).
conclusionThis is the first report, to the best of our knowledge, on optimized production of terbinafine by
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Registered trials
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