Evidence map›Paper›PMID 33116510›Full record

ArticleInternational journal of nanomedicine2020

In vitro Characterization and Release Studies of Combined Nonionic Surfactant-Based Vesicles for the Prolonged Delivery of an Immunosuppressant Model Drug.

Akhtar Rasul, Muhammad Imran Khan, Mujeeb Ur Rehman, Ghulam Abbas, Nosheen Aslam, Shabbir Ahmad, Khizar Abbas, Pervaiz Akhtar Shah, Muhammad Iqbal, Ali Mohammad Ahmed Al Subari and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 56 citations in OpenAlex.

  1. Niosomal Encapsulation ofPharmaceutics · 2026
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  7. Review
  8. Formulation and Characterization ofInternational journal of nanomedicine · 2025
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  11. Fabrication of Phytosome with Enhanced Activity ofInternational journal of nanomedicine · 2024
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Akhtar Rasul *Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.ORCID 0000-0002-9321-0087
Muhammad Imran Khan *Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Lahore, Pakistan.
Mujeeb Ur Rehman *Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.ORCID 0000-0003-4594-2598
Ghulam Abbas *Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.ORCID 0000-0003-3005-3288
Nosheen Aslam *Department of Biochemistry, Government College University, Faisalabad, Pakistan.
Shabbir Ahmad *Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macau, People's Republic of China.
Khizar Abbas *Department of Pharmacognosy, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
Pervaiz Akhtar Shah *University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
Muhammad Iqbal *Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan.
Ali Mohammad Ahmed Al Subari *Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan.
Talal Shaheer *Department of Pharmacognosy, Xian Jiaotong University, Xian, People's Republic of China.
Shahid Shah *Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.ORCID 0000-0002-7396-8341
Government College University, Faisalabad · PKGomal University · PKBahauddin Zakariya University · PKRiphah International University · PKUniversity of Macau · MOUniversity of the Punjab · PKXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCyclosporine A (CsA) is an exceptional immunosuppressant used for the treatment of immune disorders. Niosomal vesicles are promising drug carriers that are formed by self-association of nonionic surfactants and cholesterol in an aqueous phase. The objective of the study was to formulate combined nonionic surfactant based vesicles and to evaluate their in vitro characterization, release studies and in vivo studies. MATERIALS AND

methodsFive niosomal formulations (F

resultsThe size of niosome was found in the range of 427.1 nm to 972.3 nm. SEM image of optimized formulations F

conclusionThe formulation F

Indexed as

AnimalsBiological AvailabilityCholesterolCyclosporineDrug CarriersDrug LiberationImmunosuppressive AgentsLiposomesParticle SizeRabbitsSurface-Active AgentsCholesterolCyclosporineDrug CarriersImmunosuppressive AgentsLiposomesSurface-Active Agentscyclosporine Ain vitro studyniosomesnonionic surfactants

Identifiers

PMID33116510
PMCPMC7569247
OpenAlexW3092861403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.