Evidence map›Paper›PMID 33116494›Full record

ArticleInternational journal of nanomedicine2020

Multimodal Mesoporous Silica Nanocarriers for Dual Stimuli-Responsive Drug Release and Excellent Photothermal Ablation of Cancer Cells.

Vy Anh Tran, Van Giau Vo, Kyuhwan Shim, Sang-Wha Lee, Seong Soo A An

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Vy Anh Tran *Department of Chemical and Biological Engineering, Gachon University, Seongnam, Republic of Korea.
Van Giau Vo *Institute of Research and Development, Duy Tan University, Danang 550000, Vietnam.ORCID 0000-0002-9937-7865
Kyuhwan ShimDepartment of Neurology, Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of Korea.
Sang-Wha LeeDepartment of Chemical and Biological Engineering, Gachon University, Seongnam, Republic of Korea.ORCID 0000-0002-4655-9761
Seong Soo A AnDepartment of BioNano Technology, Gachon University, Seongnam 13120, Republic of Korea.ORCID 0000-0002-8123-6183
Gachon University · KRVeterans Health Service Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCore-shell types of mesoporous silica nanoparticles (MSNs) with multimodal functionalities were developed for bio-imaging, controlled drug release associated with external pH, and near-infrared radiation (NIR) stimuli, and targeted and effective chemo-photothermal therapeutics. MATERIALS AND

methodsWe synthesized and developed a core-shell type of mesoporous silica nanocarriers for fluorescent imaging, stimuli-responsive drug release, magnetic separation, antibody targeting, and chemo-photothermal therapeutics. Also, the biocompatibility, cellular uptake, cytotoxicity, and photothermal therapy on these FS3-based nanocarriers were systematically investigated.

resultsMagnetic mesoporous silica nanoparticles was prepared by coating a Fe

conclusionAlong with the facile synthesis of FS3-based nanocarriers, the integration of all these strategies into one single unit will be a prospective candidate for biomedical applications, especially in chemo-photothermal therapeutics, targeted delivery, and stimuli-responsive controlled drug release against multiple cancer cell types.

Indexed as

Drug LiberationHyperthermia, InducedPhototherapyCisplatinDoxorubicinDrug CarriersFerric CompoundsGraphiteHEK293 CellsHeLa CellsHumansIndolesNanoparticlesNeoplasmsPolymersPorosityCisplatinDoxorubicinDrug CarriersFerric Compoundsferric oxidegraphene oxideGraphiteIndolespolydopaminePolymersSilicon DioxideAu NPscancerous cellschemo-photothermal therapymesoporous silica NPsstimuli-responsive drug release

Identifiers

PMID33116494
PMCPMC7549887
OpenAlexW3092427196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.