Evidence map›Paper›PMID 33116284›Full record

ReviewNature2020

Strategic vision for improving human health at The Forefront of Genomics.

Eric D Green, Chris Gunter, Leslie G Biesecker, Valentina Di Francesco, Carla L Easter, Elise A Feingold, Adam L Felsenfeld, David J Kaufman, Elaine A Ostrander, William J Pavan and 20 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

188 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Genetic counseling and testing for Asian Americans: a systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
    Pooled it
  6. Use of Genomic Information in Health Impact Assessment is Yet to Come: A Systematic Review.International journal of environmental research and public health · 2020
    Pooled it
  7. Trial
  8. Educational considerations based on medical student use of polygenic risk information and apparent race in a simulated consultation.Genetics in medicine : official journal of the American College of Medical Genetics · 2022
    Trial
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Reprogramming of neuronal genome function and phenotype by astrocytes.bioRxiv : the preprint server for biology · 2026
    Article
  15. Review
  16. Article
  17. A scalable approach to resolving variants of uncertain significance.bioRxiv : the preprint server for biology · 2026
    Article
  18. Article
  19. Article
  20. Genomics in Health and Biomedicine.Advances in experimental medicine and biology · 2026
    Review

128 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Eric D GreenNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. egreen@nhgri.nih.gov.ORCID http://orcid.org/0000-0002-2974-3823
Chris GunterNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9369-7537
Leslie G BieseckerNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0197-3811
Valentina Di FrancescoNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Carla L EasterNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Elise A FeingoldNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Adam L FelsenfeldNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
David J KaufmanNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Elaine A OstranderNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6075-9738
William J PavanNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Adam M PhillippyNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2983-8934
Anastasia L WiseNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Jyoti Gupta DayalNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8374-1888
Britny J KishNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Allison MandichNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Christopher R WellingtonNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Kris A WetterstrandNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6866-2842
Sarah A BatesNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Darryl LejaNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Susan VasquezNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
William A GahlNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Bettie J GrahamNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Daniel L KastnerNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Paul LiuNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Laura Lyman RodriguezNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6092-8589
Benjamin D SolomonNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Vence L BonhamNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Lawrence C BrodyNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Carolyn M HutterNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Teri A ManolioNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Funding

Intramural NIH HHS Z99 HG999999
6 · The paper itself

Abstract

Starting with the launch of the Human Genome Project three decades ago, and continuing after its completion in 2003, genomics has progressively come to have a central and catalytic role in basic and translational research. In addition, studies increasingly demonstrate how genomic information can be effectively used in clinical care. In the future, the anticipated advances in technology development, biological insights, and clinical applications (among others) will lead to more widespread integration of genomics into almost all areas of biomedical research, the adoption of genomics into mainstream medical and public-health practices, and an increasing relevance of genomics for everyday life. On behalf of the research community, the National Human Genome Research Institute recently completed a multi-year process of strategic engagement to identify future research priorities and opportunities in human genomics, with an emphasis on health applications. Here we describe the highest-priority elements envisioned for the cutting-edge of human genomics going forward-that is, at 'The Forefront of Genomics'.

Indexed as

Biomedical ResearchCOVID-19Genome, HumanGenomicsHumansNational Human Genome Research Institute (U.S.)Public HealthSocial ChangeTranslational Research, BiomedicalUnited States

Identifiers

PMID33116284
PMCPMC7869889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.