Evidence map›Paper›PMID 33116279›Full record

ReviewNature reviews. Rheumatology2021

Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines.

Nigel K Arden, Thomas A Perry, Raveendhara R Bannuru, Olivier Bruyère, Cyrus Cooper, Ida K Haugen, Marc C Hochberg, Timothy E McAlindon, Ali Mobasheri, Jean-Yves Reginster

4 registry-linked trialsOpen access · greenAbstract readComparative StudyReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 300 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
300citing papers in PubMed, 16 pooled it
43.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05827003 nacompletednot on this mapstarted 2024, after this paper: background citation

The Comparison of the Effectiveness of Exercise and Topical Agent Treatments in Knee Osteoarthritis: A Randomized Controlled Trial

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2024 to 2025Enrolled79ConditionsOsteo Arthritis KneeArmsExercise, Exercise&Topical Agent, Topical Agent
NCT05877027 nacompletednot on this mapstarted 2024, after this paper: background citation

Comparison of Commonly Used Treatment Approaches in the Treatment of Gonarthrosis: Platelet-Rich Plasma, Topical Diclofenac, and Exercise

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2024 to 2025Enrolled82ConditionsGonarthrosisArmsExercise, Topical Diclofenac, Platelet-Rich-Plasma (PRP)
NCT07381621 recruitingnot on this mapstarted 2026, after this paper: background citation

A Prospective Evaluation of the Clinical Effectiveness of Perineural Dextrose and Conventional Local Anesthetic Injections in Patients With Symptomatic Knee Osteoarthritis

Typeobservational_patient_registrySponsorAnkara Training and Research HospitalRan2026 to 2026Enrolled86ConditionsKnee OsteoarthritisArmsPerineural 5% Dextrose Injection, Perineural Local Anesthetic Injection
NCT07395427 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Comparison of the Effects of Basic Body Awareness Therapy to Conventional Physiotherapy and Home Exercise Program in Individuals With Knee Osteoarthritis

TypeinterventionalSponsorHacettepe UniversityRan2025 to 2026Enrolled63ConditionsKnee OsteoarthritisArmsBBAT plus home exercise programme, Conventional physiotherapy plus home exercise programme, Home exercise programme
3 · Its place in the literature

Who cites it

300 citing papers in PubMed, 16 syntheses or guidelines pooled it, 518 citations in OpenAlex.

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240 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 8 countries.

Nigel K ArdenVersus Arthritis Centre for Sport, Exercise and Osteoarthritis, University of Oxford, Oxford, UK.ORCID 0000-0002-3452-3382
Thomas A PerryVersus Arthritis Centre for Sport, Exercise and Osteoarthritis, University of Oxford, Oxford, UK. thomas.perry@ndorms.ox.ac.uk.ORCID 0000-0002-0499-3033
Raveendhara R BannuruCenter for Treatment Comparison and Integrative Analysis, Division of Rheumatology, Tufts Medical Center, Boston, MA, USA.ORCID 0000-0002-8069-5783
Olivier BruyèreWHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium.
Cyrus CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.ORCID 0000-0003-3510-0709
Ida K HaugenDepartment of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Marc C HochbergDepartments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Timothy E McAlindonCenter for Treatment Comparison and Integrative Analysis, Division of Rheumatology, Tufts Medical Center, Boston, MA, USA.
Ali MobasheriResearch Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland.ORCID 0000-0001-6261-1286
Jean-Yves ReginsterWHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium.
University of Liège · BETufts Medical Center · USDiakonhjemmet Hospital · NOUniversity of Maryland, Baltimore · USUniversity of Oxford · GBUtrecht University · NL

Funding

Department of Health 10/33/04Medical Research Council G0400491Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2
6 · The paper itself

Abstract

Knee osteoarthritis (OA) is a heterogeneous disease associated with substantial effects on quality of life, and its clinical management is difficult. Among the several available guidelines for the management of knee OA, those from OARSI and ESCEO were updated in 2019. Here, we examine the similarities and differences between these two guidelines and provide a narrative to help guide health-care providers through the complexities of non-surgical management of knee OA. OARSI and ESCEO both recommend education, structured exercise and weight loss as core treatments, topical NSAIDs as first-line treatments and oral NSAIDs and intra-articular injections for persistent pain. Low-dose, short-term acetaminophen, pharmaceutical grade glucosamine and chondroitin sulfate are recommended by ESCEO whereas OARSI strongly recommends against their use (including all glucosamine and chondroitin formulations). Despite this difference, the two guidelines are consistent in the majority of their recommendations and provide useful treatment recommendations for individuals with OA and health-care providers.

Indexed as

Administration, TopicalAgedAged, 80 and overAnti-Inflammatory Agents, Non-SteroidalChondroitin SulfatesConsensusEvidence-Based MedicineExercise TherapyGlucosamineHealth PersonnelHumansInjections, Intra-ArticularOsteoarthritis, KneePractice Guidelines as TopicQuality of LifeWeight LossAnti-Inflammatory Agents, Non-SteroidalChondroitin SulfatesGlucosamine

Identifiers

PMID33116279
OpenAlexW3094817545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.