ArticleScientific reports2020
Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- Domestication-Driven Expansion and Structural Convergence of the Porcine Antiviral Interferon Repertoire.Biomolecules · 2026Article
- Haematopoietic Traits in Indigenous and Modern Pig Breeds Are Modulated by Housing System and Developmental Stage.Animal genetics · 2026Article
- Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs.Genetics, selection, evolution : GSE · 2026Article
- Genetic and non-genetic factors distinctly shape the variation of the immune response in cattle.Nature communications · 2026Article
- Porcine genetic markers of immunocompetence shape the immune response to a classical swine fever virus subunit vaccine.Frontiers in cellular and infection microbiology · 2026Article
- Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs.Scientific reports · 2025Article
- Co-occurring microbial guilds in pig fecal microbiota: key drivers and effects on host performance.Genetics, selection, evolution : GSE · 2025Article
- Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of 232 complex traits in pigs.National science review · 2025Article
- Unveiling regulatory variants in the blood transcriptome and their association with immunity traits in pigs.Frontiers in immunology · 2025Article
- Insights into genetic determinants of piglet survival during a PRRSV outbreak.Veterinary research · 2024Article
- Identifying Significant SNPs of the Total Number of Piglets Born and Their Relationship with Leg Bumps in Pigs.Biology · 2024Article
- Selection for Resilience in Livestock Production Systems.International journal of molecular sciences · 2024Review
- Identification of genomic regions associated with fatty acid metabolism across blood, liver, backfat and muscle in pigs.Genetics, selection, evolution : GSE · 2024Article
- Expression genome-wide association study identifies key regulatory variants enriched with metabolic and immune functions in four porcine tissues.BMC genomics · 2024Article
- Multivariate genome-wide associations for immune traits in two maternal pig lines.BMC genomics · 2023Article
- Copy Number Variation onMicrobiology spectrum · 2023Article
- On the holobiont 'predictome' of immunocompetence in pigs.Genetics, selection, evolution : GSE · 2023Article
- Plasma protein levels of young healthy pigs as indicators of disease resilience.Journal of animal science · 2023Article
- Genetic architecture of innate and adaptive immune cells in pigs.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inclusion of health-related traits, or functionally associated genetic markers, in pig breeding programs could contribute to produce more robust and disease resistant animals. The aim of the present work was to study the genetic determinism and genomic regions associated to global immunocompetence and health in a Duroc pig population. For this purpose, a set of 30 health-related traits covering immune (mainly innate), haematological, and stress parameters were measured in 432 healthy Duroc piglets aged 8 weeks. Moderate to high heritabilities were obtained for most traits and significant genetic correlations among them were observed. A genome wide association study pointed out 31 significantly associated SNPs at whole-genome level, located in six chromosomal regions on pig chromosomes SSC4, SSC6, SSC17 and SSCX, for IgG, γδ T-cells, C-reactive protein, lymphocytes phagocytic capacity, total number of lymphocytes, mean corpuscular volume and mean corpuscular haemoglobin. A total of 16 promising functionally-related candidate genes, including CRP, NFATC2, PRDX1, SLA, ST3GAL1, and VPS4A, have been proposed to explain the variation of immune and haematological traits. Our results enhance the knowledge of the genetic control of traits related with immunity and support the possibility of applying effective selection programs to improve immunocompetence in pigs.
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