ArticleJournal of atherosclerosis and thrombosis2021
Relationships between Smoking Status, Cardiovascular Risk Factors, and Lipoproteins in a Large Japanese Population.
Article in Journal of atherosclerosis and thrombosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 47 citations in OpenAlex.
- Distribution of LDL-Cholesterol Levels and Their Associations With Cardiovascular Outcomes in Young Adults Under 40 Years in South Korea: A Nationwide Cohort Study.Journal of lipid and atherosclerosis · 2026Article
- Association between cardiometabolic index and major adverse cardio-cerebral events and all-cause mortality in patients with degenerative aortic stenosis: a retrospective cohort study.Journal of thoracic disease · 2026Article
- Non-HDL Cholesterol and Residual Cardiometabolic Risk in Middle Eastern Patients with Atherosclerotic Cardiovascular Disease.Healthcare (Basel, Switzerland) · 2026Article
- Association of Hyperbilirubinemia with Lipid Profile and Lipid-Related Diseases: A Large Community-Based Cohort Study.Journal of clinical medicine · 2026Article
- Association of active and passive smoking with noncommunicable diseases in a large health check-up population: A cross-sectional study in Changzhi, Shanxi province, China.Tobacco induced diseases · 2026Article
- Smoking shapes the relationship between metabolic biomarkers and femoral-neck bone mineral density: A stratified analysis by smoking status.Tobacco induced diseases · 2026Article
- Examining the interplay between sdLDL, resistin, and BMI.Scientific reports · 2025Article
- Determinants and sequelae of smoking: prevalence, incidence, and cessation among male adults in Abu dhabi, United Arab Emirates - a retrospective cohort study.BMC public health · 2025Article
- Evaluation of dyslipidemia based on ATP III guideline in adults in Southwest Iran: a population-based study.Scientific reports · 2025Article
- Impact of lifestyle behaviors on the development of lifestyle diseases: A retrospective cohort study.PloS one · 2025Article
- Berberine Intervention Mitigates Myocardial Ischemia-Reperfusion Injury in a Rat Model: Mechanistic Insights via miR-184 Signaling.Biologics : targets & therapy · 2025Article
- Smoking-Associated Changes in Gene Expression in Coronary Artery Disease Patients Using Matched Samples.Current issues in molecular biology · 2024Article
- Twin Study: The Factors Affecting the Serum LDL-C and HDL-C Levels and an RNA-Seq Analysis in Mononuclear Cells in Monozygotic Twins.Journal of atherosclerosis and thrombosis · 2024Article
- Relationship Between Smoking and Lipid Profile in Four Primary Health Care Units: A Research Study.Cureus · 2024Article
- The inverse associations of glycine and histidine in diet with hyperlipidemia and hypertension.Nutrition journal · 2024Article
- Dairy intake and cardiovascular diseases risk factors: a cross-sectional study on Iranian obese and overweight women.BMC public health · 2024Article
- Association between lipid profiles and cigarette smoke among adults in the Persian cohort (Shahedieh) study.BMC public health · 2024Article
- Machine Learning Reveals Impacts of Smoking on Gene Profiles of Different Cell Types in Lung.Life (Basel, Switzerland) · 2024Article
- Degree of joint risk factor control and hazard of mortality in diabetes patients: a matched cohort study in UK Biobank.BMC medicine · 2024Article
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Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsSmoking is a major risk factor for cardiovascular disease (CVD), a leading cause of death and disability. Other CVD risk factors include age, gender, hypertension, diabetes, increased low-density lipoprotein cholesterol (LDL-C) and decreased high-density lipoprotein cholesterol (HDL-C). Our goal was to assess relationships between smoking status and CVD risk factors, with a focus on direct LDL-C, HDL-C, triglycerides (TG) and small dense LDL-C (sdLDL-C).
methodsA total of 34,497 Japanese men and women, mean age 51 years, had their CVD risk factors including fasting serum total cholesterol, TG, HDL-C, sdLDL-C, and direct LDL-C assessed. One-way ANOVA and multiple linear regression analyses were carried to assess the interrelationships of these parameters with smoking.
resultsIn both men and women, current smokers had significantly (p＜0.001) higher median TG (+19.6%, +16.9%) and sdLDL-C levels (+12.7%, +4.2%) levels, and significantly (p＜0.001) lower HDL-C levels (-7.3%, -4.3%) than non-smokers. They were also significantly (p＜0.05) more likely to have TG values ＞150 mg/dL (+56.8%, +116.3%), sdLDL-C ＞40.1 mg/dL (+28.8%, +44.9%), and HDL-C ＜40 mg/dL (+89.8%, +114.3%). Ex-smokers generally had lipid values that were intermediate between non-smokers and current smokers. Multivariate analysis confirmed the significance of these relationships.
conclusionOur data indicate that current cigarette smoking is associated with increased TG and sdLDL-C levels, as well as decreased HDL-C levels. Furthermore, smoking effect on lipid profiles remain after cessation. These data provide further justification for smoking cessation.
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