Evidence map›Paper›PMID 33115988›Full record

ArticleExperimental animals2021

PHF24 is expressed in the inhibitory interneurons in rats.

Yuki Numakura, Risa Uemura, Miyuu Tanaka, Takeshi Izawa, Jyoji Yamate, Takashi Kuramoto, Takehito Kaneko, Tomoji Mashimo, Takashi Yamamoto, Tadao Serikawa and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental animals, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Yuki NumakuraLaboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.
Risa UemuraLaboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.
Miyuu TanakaLaboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.
Takeshi IzawaLaboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.
Jyoji YamateLaboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.
Takashi KuramotoInstitute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Takehito KanekoLaboratory of Animal Reproduction and Development, Graduate School of Science and Engineering, Iwate University, 4-35 Ueda, Morioka-shi, Iwate 020-8551, Japan.
Tomoji MashimoDivision of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, the University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Takashi YamamotoMolecular Genetics Laboratory, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan.
Tadao SerikawaInstitute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Mitsuru KuwamuraLaboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.
Osaka Prefecture University · JPHiroshima University · JPIwate University · JPKyoto University · JPThe University of Tokyo · JPTokyo University of Agriculture · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noda epileptic rat (NER) is a mutant model for epilepsy that exhibits spontaneous generalized tonic-clonic seizure. Epileptogenesis of NER remains to be elucidated; but it is detected an insertion of an endogenous retrovirus sequence in intron 2 of the PHD finger protein 24 (Phf24) gene, encoding Gαi-interacting protein (GINIP). Phf24 is a strong candidate gene for epileptogenesis in NER. PHF24 modulates GABA

Indexed as

Gene ExpressionGenetic Association StudiesAnimalsCalbindin 2CalbindinsCentral Nervous SystemDisease Models, Animalgamma-Aminobutyric AcidHomeodomain ProteinsImmunohistochemistryInterneuronsIntracellular Signaling Peptides and ProteinsOlfactory BulbRatsRats, Inbred F344SeizuresCalbindin 2Calbindinsgamma-Aminobutyric AcidGINIP protein, ratHomeodomain ProteinsIntracellular Signaling Peptides and ProteinsPHF24 protein, humanepilepsyGABAB receptorinhibitory interneuronmutant ratPHF24

Identifiers

PMID33115988
PMCPMC7887615
OpenAlexW3095036280

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.