Evidence map›Paper›PMID 33115949›Full record

ArticleScience translational medicine2020

A probiotic yeast-based immunotherapy against

Kevin Chen, Yixuan Zhu, Yongrong Zhang, Therwa Hamza, Hua Yu, Ashley Saint Fleur, James Galen, Zhiyong Yang, Hanping Feng

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
1.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 126 citations in OpenAlex.

  1. Review
  2. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Gut microbes · 2025
    Article
  12. Review
  13. Review
  14. De novo design of potent inhibitors of clostridial family toxins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kevin ChenDepartment of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.ORCID 0000-0002-5120-6119
Yixuan ZhuCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-0669-5918
Yongrong ZhangDepartment of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
Therwa HamzaDepartment of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.ORCID 0000-0002-2616-5378
Hua YuFZata Inc., Halethorpe, MD 21227, USA.ORCID 0000-0002-1141-9750
Ashley Saint FleurDepartment of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
James GalenCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-4202-0213
Zhiyong YangFZata Inc., Halethorpe, MD 21227, USA.
Hanping FengDepartment of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD 21201, USA. hfeng@umaryland.edu.ORCID 0000-0002-8685-1812
University of Maryland, Baltimore · USHal Technology (United States) · US

Funding

Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
Probiotic yeast secreting single-domain antibodies to prevent Clostridium difficile and Campylobacter jejuni diseaseU19AI142725 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2019 to 2023
$12.5M
A Novel Humanized Tetra-specific Antibody against Clostridium difficile InfectionR01AI132207 · NIAID · FZATA, INC. · PI FENG, HANPING, YANG, ZHIYONG · 2017 to 2022
$8.1M
Preventing norovirus and Clostridium difficile gastroenteritis by engineered probiotic yeast Saccharomyces boulardii secreting multi-specific single-domain antibodiesR01AI148357 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FENG, HANPING, YUAN, LIJUAN · 2020 to 2024
$3.1M
A Yeast-based Immunotherapy against Clostridioides difficile infectionR44AI155277 · NIAID · FZATA, INC. · PI YANG, ZHIYONG · 2020 to 2023
$2.6M
A Yeast based Immunotherapy against Clostridium difficile InfectionR43AI129044 · NIAID · FZATA, INC. · PI YANG, ZHIYONG · 2017 to 2017
$225k
Novel Immunotherapies for Comorbidity of Clostridium difficile and Inflammatory Bowel DiseaseR43AI136108 · NIAID · FZATA, INC. · PI YANG, ZHIYONG · 2018 to 2018
$225k
NIAID NIH HHS R01 AI132207NIAID NIH HHS R01 AI148357NIAID NIH HHS R43 AI129044NIAID NIH HHS R43 AI136108NIAID NIH HHS R44 AI155277NIAID NIH HHS U19 AI109776NIAID NIH HHS U19 AI142725
6 · The paper itself

Abstract

Antibiotic-resistant

Indexed as

Bacterial ToxinsClostridioides difficileClostridium InfectionsProbioticsAnimalsBacterial ProteinsClostridioidesEnterotoxinsHumansImmunotherapyMiceSaccharomyces cerevisiaeBacterial ProteinsBacterial ToxinsEnterotoxins

Identifiers

PMID33115949
PMCPMC7692727
OpenAlexW3096674473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.