ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
The Input-Output Relation of Primary Nociceptive Neurons is Determined by the Morphology of the Peripheral Nociceptive Terminals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Opposite regulation of medullary pain-related projection neuron excitability in acute and chronic pain.Science advances · 2025Article
- Slow depolarizing electrical stimuli reveal differential time courses of nociceptor recovery after prolonged topical capsaicin in human skin.European journal of pain (London, England) · 2025Article
- From Compression to Itch: Exploring the Link Between Nerve Compression and Neuropathic Pruritus.American journal of clinical dermatology · 2025Review
- Changes of Trigeminal Ganglion Neurons Innervating the Temporomandibular Joint in Chronic Pain Rat Model.International journal of dentistry · 2024Article
- Diabetes-Induced Amplification of Nociceptive DRG Neuron Output by Upregulation of Somatic T-Type CaBiomolecules · 2023Article
- Measuring pain and nociception: Through the glasses of a computational scientist. Transdisciplinary overview of methods.Frontiers in network physiology · 2023Review
- Scratching increases epidermal neuronal branching and alters psychophysical testing responses in atopic dermatitis and brachioradial pruritus.Frontiers in molecular neuroscience · 2023Article
- Corneal nerves and their role in dry eye pathophysiology.Experimental eye research · 2022Review
- mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation.The Journal of clinical investigation · 2022Article
- Stimulus-Evoked Activity Modulation of In Vitro Engineered Cortical and Hippocampal Networks.Micromachines · 2022Article
- MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound.iScience · 2021Article
- Optical Assessment of Nociceptive TRP Channel Function at the Peripheral Nerve Terminal.International journal of molecular sciences · 2021Review
- DecipheringFrontiers in cellular neuroscience · 2021Article
- Electrically Evoked Itch in Human Subjects.Frontiers in medicine · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The output from the peripheral terminals of primary nociceptive neurons, which detect and encode the information regarding noxious stimuli, is crucial in determining pain sensation. The nociceptive terminal endings are morphologically complex structures assembled from multiple branches of different geometry, which converge in a variety of forms to create the terminal tree. The output of a single terminal is defined by the properties of the transducer channels producing the generation potentials and voltage-gated channels, translating the generation potentials into action potential (AP) firing. However, in the majority of cases, noxious stimuli activate multiple terminals; thus, the output of the nociceptive neuron is defined by the integration and computation of the inputs of the individual terminals. Here, we used a computational model of nociceptive terminal tree to study how the architecture of the terminal tree affects the input-output relation of the primary nociceptive neurons. We show that the input-output properties of the nociceptive neurons depend on the length, the axial resistance (Ra), and location of individual terminals. Moreover, we show that activation of multiple terminals by a capsaicin-like current allows summation of the responses from individual terminals, thus leading to increased nociceptive output. Stimulation of the terminals in simulated models of inflammatory or neuropathic hyperexcitability led to a change in the temporal pattern of AP firing, emphasizing the role of temporal code in conveying key information about changes in nociceptive output in pathologic conditions, leading to pain hypersensitivity.
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