ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Spatially Specific Working Memory Activity in the Human Superior Colliculus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Human superior colliculus pathways represent the form and motion of looming objects.Cell reports · 2026Article
- Sensory reformatting for a working visual memory.Trends in cognitive sciences · 2025Review
- Effector general representation of movement goals in human frontal and parietal cortex.NeuroImage · 2025Article
- Perturbing human V1 degrades the fidelity of visual working memory.Nature communications · 2025Article
- Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory.Quantitative imaging in medicine and surgery · 2024Article
- Neural population dynamics of human working memory.Current biology : CB · 2023Article
- Mnemonic representations in human lateral geniculate nucleus.Frontiers in behavioral neuroscience · 2023Article
- A Midbrain Inspired Recurrent Neural Network Model for Robust Change Detection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Review
- Alcohol use severity and the neural correlates of the effects of sleep disturbance on sustained visual attention.Journal of psychiatric research · 2021Article
- Balancing Flexibility and Interference in Working Memory.Annual review of vision science · 2021Review
- Working memory representations in visual cortex mediate distraction effects.Nature communications · 2021Article
- Persistent Activity During Working Memory From Front to Back.Frontiers in neural circuits · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Theoretically, working memory (WM) representations are encoded by population activity of neurons with distributed tuning across the stored feature. Here, we leverage computational neuroimaging approaches to map the topographic organization of human superior colliculus (SC) and model how population activity in SC encodes WM representations. We first modeled receptive field properties of voxels in SC, deriving a detailed topographic organization resembling that of the primate SC. Neural activity within human (5 male and 1 female) SC persisted throughout a retention interval of several types of modified memory-guided saccade tasks. Assuming an underlying neural architecture of the SC based on its retinotopic organization, we used an encoding model to show that the pattern of activity in human SC represents locations stored in WM. Our tasks and models allowed us to dissociate the locations of visual targets and the motor metrics of memory-guided saccades from the spatial locations stored in WM, thus confirming that human SC represents true WM information. These data have several important implications. They add the SC to a growing number of cortical and subcortical brain areas that form distributed networks supporting WM functions. Moreover, they specify a clear neural mechanism by which topographically organized SC encodes WM representations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.