ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Differential Encoding of Predator Fear in the Ventromedial Hypothalamus and Periaqueductal Grey.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- An intralayer microcircuit in the temporal association cortex underlies sensory-induced escape in mice.Nature communications · 2026Article
- A shared speed encoding model for running and backing away behaviours in segregated neural circuits.Nature communications · 2026Article
- Fleeing is believing: adaptive behavior under social threat as an inference process.Frontiers in neural circuits · 2026Article
- Fos expression in the periaqueductal gray, but not the ventromedial hypothalamus, is correlated with psychosocial stress-induced cocaine-seeking behavior in rats.Addiction neuroscience · 2025Article
- Article
- Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat.eLife · 2025Article
- Hypothalamic representation of the imminence of predator threat detected by the vomeronasal organ in mice.eLife · 2024Article
- Chemogenetic Excitation of Ventromedial Hypothalamic Steroidogenic Factor 1 (SF1) Neurons Increases Muscle Thermogenesis in Mice.Biomolecules · 2024Article
- Tonically active GABAergic neurons in the dorsal periaqueductal gray control instinctive escape in mice.Current biology : CB · 2024Article
- Brain Mechanisms Underlying Panic Attack and Panic Disorder.Neuroscience bulletin · 2024Review
- Article
- Interplay between hippocampal TACR3 and systemic testosterone in regulating anxiety-associated synaptic plasticity.Molecular psychiatry · 2024Article
- Freud's 1926 conjecture is confirmed: evidence from the dorsal periaqueductal gray in mice that human psychological defense against internal instinctual threat evolved from animal motor defense against external predatory threat.Frontiers in psychology · 2024Review
- A novel subdivision of the bed nucleus of stria terminalis in monkey, rat, and mouse brains.The Journal of comparative neurology · 2023Article
- Bed nucleus of the stria terminalis GABA neurons are necessary for changes in foraging behaviour following an innate threat.The European journal of neuroscience · 2023Article
- Anterior hypothalamic parvalbumin neurons are glutamatergic and promote escape behavior.Current biology : CB · 2023Article
- Advances in neural circuits of innate fear defense behavior.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Review
- Orchestration of innate and conditioned defensive actions by the periaqueductal gray.Neuropharmacology · 2023Review
- Characterization of ventromedial hypothalamus activity during exposure to innate and conditioned threats.The European journal of neuroscience · 2023Article
- Bed Nucleus of the Stria Terminalis GABA neurons are necessary for changes in foraging behavior following an innate threat.bioRxiv : the preprint server for biology · 2023Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The ventromedial hypothalamus is a central node of the mammalian predator defense network. Stimulation of this structure in rodents and primates elicits abrupt defensive responses, including flight, freezing, sympathetic activation, and panic, while inhibition reduces defensive responses to predators. The major efferent target of the ventromedial hypothalamus is the dorsal periaqueductal gray (dPAG), and stimulation of this structure also elicits flight, freezing, and sympathetic activation. However, reversible inhibition experiments suggest that the ventromedial hypothalamus and periaqueductal gray play distinct roles in the control of defensive behavior, with the former proposed to encode an internal state necessary for the motivation of defensive responses, while the latter serves as a motor pattern initiator. Here, we used electrophysiological recordings of single units in behaving male mice exposed to a rat to investigate the encoding of predator fear in the dorsomedial division of the ventromedial hypothalamus (VMHdm) and the dPAG. Distinct correlates of threat intensity and motor responses were found in both structures, suggesting a distributed encoding of sensory and motor features in the medial hypothalamic-brainstem instinctive network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.