ArticleJournal of neurointerventional surgery2021
Characterization of thrombus composition with multimodality CT-based imaging: an in-vitro study.
Article in Journal of neurointerventional surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Dual-energy computed tomography venography parameters as potential indicators for pulmonary embolism in deep vein thrombosis.Journal of thoracic disease · 2026Article
- Clinical image analysis to build patient-specific models of acute ischemic stroke patients.Physical and engineering sciences in medicine · 2026Article
- Experimental Characterisation of Differently Composed Thrombus Entities with Spectral-Detector-CT.Neurology international · 2026Article
- Thrombus iodine-based perviousness is associated with recanalisation and functional outcomes in endovascular thrombectomy.Stroke and vascular neurology · 2025Article
- Dual-Energy CT-Based Assessment of Thrombotic Heterogeneity for Predicting Stroke Source and Response to Machine Thrombectomy: A Step Toward Visualization Thrombus Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Management of Biventricular and Left Atrium Thrombi in a Patient With Acute Myocardial Infarction.JACC. Case reports · 2025Article
- Dual-layer dual-energy CT characterization of thrombus composition in acute pulmonary embolism and chronic thromboembolic pulmonary hypertension.The international journal of cardiovascular imaging · 2025Article
- Thrombus Composition in Cerebral Venous Thrombosis.Stroke research and treatment · 2025Article
- Ischemic core detection threshold of computed tomography perfusion (CTP) in acute stroke.La Radiologia medica · 2024Article
- Thrombus discrimination with electron density: potential implications for non-contrast computed tomography imaging.Cardiovascular diagnosis and therapy · 2024Article
- Clinical Applications of Dual-Energy Computed Tomography for Acute Ischemic Stroke.Stroke (Hoboken, N.J.) · 2024Review
- Experimental Evaluation of the Effectiveness of Aspiration-Based Techniques to Treat Different Types of Acute Thromboembolic Occlusions in the Femoropopliteal Vascular System Using an In Vitro Flow Model.Cardiovascular and interventional radiology · 2022Article
- No Histological Difference between Large Atherosclerotic and Cardiogenic Embolic Thrombus.Oxidative medicine and cellular longevity · 2022Article
- MicroCT Can Characterize Clots Retrieved With Mechanical Thrombectomy From Acute Ischemic Stroke Patients-A Preliminary Report.Frontiers in neurology · 2022Article
- In Vitro Study of Blood Clot Identification and Composition Assessment by Different Magnetic Resonance Sequences.Cureus · 2021Article
- Multimodality Characterization of the Clot in Acute Stroke.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCT is the most commonly used imaging modality for acute ischemic stroke evaluation. There is growing interest to use pre-operative imaging to characterize clot composition in stroke. We performed an in-vitro study examining the ability of various CT techniques in differentiation between different clot types.
methodsFive clot types with varying fibrin and red blood cells (RBCs) densities (5% RBC and 95% fibrin; 25% RBC and 75% fibrin; 50% RBC and 50% fibrin; 75% RBC and 25% fibrin; 95% RBC and 5% fibrin) were prepared and scanned using various CT scanning protocols (single-energy, dual-energy, photon-counting detector CT, mixed images, and virtual monoenergetic images). Martius Scarlett Blue trichrome staining was performed to confirm the composition of each clot. Mean CT values of each type of clot under different scanning protocol were calculated and compared.
resultsMean CT values of the CT numbers in the five clot specimens for 5%, 25%, and 50% RBC clot were similar across modalities, and increased significantly for 75% and 95% RBC clots (P<0.0001). Mean CT values are highest in the Mono +50 keV images in each type of clot, and they were also significantly higher than all other imaging protocols (P<0.001). Dual-energy CT with Mono +50 keV images showed the greatest difference between attenuation in each type of clot.
conclusionMono +50 keV dual-energy CT scan may be helpful for differentiating between RBC-rich and fibrin-rich thrombi seen in large-vessel occlusion patients.
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