ArticleCancer research2021
Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone.
Open access · greenAbstract read
In one paragraph
Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 54 citations in OpenAlex.
- Nuclear-specific reductive carboxylation of alpha-ketoglutarate fuels histone acetylation to induce chromatin accessibility and gene activation.Nature communications · 2026Article
- The ClockJournal of orthopaedic surgery and research · 2026Article
- Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic networks to breast cancer survival.GeroScience · 2026Article
- NCOA2 promotes the return of hematopoietic stem cells to quiescence after irradiation stress by regulating FOXO3a-dependent mitophagy.HemaSphere · 2026Article
- HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma.Cell death & disease · 2025Article
- Roles of SIRT3 in aging and aging-related diseases.International journal of biological sciences · 2025Review
- The role of acetylation and deacetylation in cancer metabolism.Clinical and translational medicine · 2025Review
- LHPP Attenuates Lipid Dysfunction of Uveal Melanoma by Relieving the Histidine Phosphorylation of ACO2.Research (Washington, D.C.) · 2025Article
- Molecular Sentinels: Unveiling the Role of Sirtuins in Prostate Cancer Progression.International journal of molecular sciences · 2024Review
- Comprehensive analysis of lysine lactylation and its potential biological significance in clear cell renal cell carcinoma.European journal of medical research · 2024Article
- Sirtuin insights: bridging the gap between cellular processes and therapeutic applications.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- The role of circular RNA during the urological cancer metastasis: exploring regulatory mechanisms and potential therapeutic targets.Cancer metastasis reviews · 2024Review
- Androgen Receptor-Interacting Proteins in Prostate Cancer Development and Therapy Resistance.The American journal of pathology · 2024Review
- Function of Steroid Receptor Coactivators in T Cells and Cancers: Implications for Cancer Immunotherapy.Critical reviews in immunology · 2024Review
- Review
- Mitochondrial Sirtuins in Cancer: A Revisited Review from Molecular Mechanisms to Therapeutic Strategies.Theranostics · 2024Review
- ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes.Communications biology · 2023Article
- Emerging proteins involved in castration‑resistant prostate cancer via the AR‑dependent and AR‑independent pathways (Review).International journal of oncology · 2023Review
- PTP4A1 promotes oral squamous cell carcinoma (OSCC) metastasis through altered mitochondrial metabolic reprogramming.Cell death discovery · 2023Article
- Article
Corrections and comments
- Commented on byUro-Science.2021
Authors and funding
15 authors at 3 institutions in 1 country.
Abhisha Sawant Dessai *Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Mayrel Palestino Dominguez *Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.ORCID https://orcid.org/0000-0002-1442-9719
Uan-I ChenDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
John HasperDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.ORCID https://orcid.org/0000-0002-6821-8458
Christian PrechtlDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Cuijuan YuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
Eriko KatsutaDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.ORCID https://orcid.org/0000-0001-5862-2919
Tao DaiDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Bokai ZhuDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID https://orcid.org/0000-0003-0827-5757
Sung Yun JungDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.ORCID https://orcid.org/0000-0003-1521-7977
Nagireddy PutluriDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
Kazuaki TakabeDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.ORCID https://orcid.org/0000-0002-6435-4241
Xiang H-F ZhangDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.ORCID https://orcid.org/0000-0002-5674-8670
Bert W O'MalleyDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
Subhamoy DasguptaDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York. Subhamoy.Dasgupta@RoswellPark.org.ORCID https://orcid.org/0000-0001-7167-908X
Roswell Park Comprehensive Cancer Center · USBaylor College of Medicine · USUniversity of Pittsburgh · US
Funding
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MProject 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythmsP01DK113954 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI O'MALLEY, BERT W · 2018 to 2022
$7.9MDecoding the nuclear metabolic processes regulating gene transcriptionDP2CA260421 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI DASGUPTA, SUBHAMOY · 2020 to 2024
$2.5MMechanisms of metabolic stress-induced transcriptional regulation in prostate cancerR01CA252092 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI DASGUPTA, SUBHAMOY · 2021 to 2025
$1.9MINVESTIGATING THE ROLE OF THE TRANSCRIPTIONAL COREGULATOR SRC-2 IN CASTRATION RESISTANT PROSTATE CANCERK22CA207578 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI DASGUPTA, SUBHAMOY · 2017 to 2019
$620kNCI NIH HHS DP2 CA260421NCI NIH HHS K22 CA207578NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA252092NIDDK NIH HHS P01 DK113954
Abstract
Metabolic dysregulation is a known hallmark of cancer progression, yet the oncogenic signals that promote metabolic adaptations to drive metastatic cancer remain unclear. Here, we show that transcriptional repression of mitochondrial deacetylase sirtuin 3 (
Indexed as
Gene Expression Regulation, NeoplasticAconitate HydrataseAnimalsApoptosisBiomarkers, TumorBone NeoplasmsCell ProliferationHumansMaleMiceMice, NudeMitochondriaNuclear Receptor Coactivator 3Prostatic NeoplasmsReceptors, AndrogenSirtuin 3ACO2 protein, humanAconitate HydrataseAR protein, humanBiomarkers, TumorNCOA3 protein, humanNuclear Receptor Coactivator 3Receptors, AndrogenSIRT3 protein, humanSirtuin 3
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.