ArticleBMJ open respiratory research2020
Predictors of postoperative acute exacerbation of interstitial lung disease: a case-control study.
Article in BMJ open respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 6 citations in OpenAlex.
- Integrative single-cell and bulk transcriptomic analyses identifyJournal of thoracic disease · 2026Article
- Open retrograde carotid artery stenting with balloon guiding catheter under local anesthesia for common carotid artery origin stenosis: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Mortality and factors associated with acute exacerbation after non-cardiac surgery in patients with interstitial pneumonia: a retrospective study.Korean journal of anesthesiology · 2025Article
- Secondary analysis of preoperative predictors for acute postoperative exacerbation in interstitial lung disease.Scientific reports · 2023Article
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- Management of Lung Cancer in the Patient with Interstitial Lung Disease.The oncologist · 2023Review
- Anti-EJ antibody-positive interstitial pneumonia with breast cancer improved by combining immunosuppressive therapy and chemotherapy.Respiratory medicine case reports · 2023Article
- Survey of acute exacerbation after nonpulmonary surgery in patients with interstitial pneumonia.JA clinical reports · 2021Article
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8 authors at 1 institution in 1 country.
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Abstract
introductionPatients with interstitial lung disease (ILD) are known to develop an acute exacerbation (AE) after surgery. Previous studies have evaluated the predictors of postoperative AE. However, it remains unclear whether the results of those studies can be generalised to patients with different types of ILD and/or extrapolated to those who undergo non-pulmonary surgery. This study aimed to elucidate the predictors of the development of AE after surgery with general anaesthesia in patients with ILD.
methodsWe conducted a nested matched case-control study of 700 patients from an initial cohort of 50 840 patients. We excluded those who underwent solid organ or bone marrow transplantation. The cases were patients with ILD who developed AE within 30 days postoperatively, whereas the controls did not develop AE. Each case (n=28) was matched with four controls (n=112) for sex, year of surgery and multiple operations within 30 days. Furthermore, a multivariable conditional logistic regression analysis was used to identify significant predictors, as indicated by a p value of <0.05.
resultsAfter adjusting for potential confounders, the multivariable conditional logistic regression analysis identified honeycombing on CT (OR 3.09; 95% CI 1.07 to 8.92), a per cent predicted FVC <80% (OR 4.21; 95% CI 1.46 to 12.2) and an ARISCAT score ≥45 (OR 6.14; 95% CI 2.10 to 18.0) significantly associated with the development of postoperative AE.
conclusionsWe found that the three factors were independent predictors for the development of postoperative AE in patients with ILD. These predictors are advantageous because they can be readily evaluated before surgery by surgeons and anaesthesiologists even without consulting experienced pulmonologists.
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