Evidence map›Paper›PMID 33115736›Full record

ArticleScience advances2020

Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo.

Arijit Ghosh, Ling Li, Liyi Xu, Ranjeet P Dash, Neha Gupta, Jenny Lam, Qianru Jin, Venkata Akshintala, Gayatri Pahapale, Wangqu Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
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  17. Review
  18. Challenges in IBD Research 2024: Novel Technologies.Inflammatory bowel diseases · 2024
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arijit GhoshDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0003-3449-2317
Ling LiDivision of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0003-4498-9466
Liyi XuDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0001-7946-4139
Ranjeet P DashJohns Hopkins Drug Discovery, Baltimore, MD 21205, USA.
Neha GuptaDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-7362-2383
Jenny LamJohns Hopkins Drug Discovery, Baltimore, MD 21205, USA.ORCID 0000-0002-7915-3530
Qianru JinDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0003-3182-8188
Venkata AkshintalaDivision of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-8909-1951
Gayatri PahapaleDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0003-2434-0918
Wangqu LiuDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-6526-5398
Anjishnu SarkarDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0001-9691-5851
Rana RaisJohns Hopkins Drug Discovery, Baltimore, MD 21205, USA.ORCID 0000-0003-4059-2453
David H GraciasDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. dgracias@jhu.edu fselaru1@jhmi.edu.ORCID 0000-0003-2735-4725
Florin M SelaruDivision of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. dgracias@jhu.edu fselaru1@jhmi.edu.ORCID 0000-0001-7990-8238

Funding

Tissue biopsying with wireless microgrippers within gastrointestinal tractR01EB017742 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI David H Gracias, Florin Selaru · 2014 to 2026
$6.6M
NIBIB NIH HHS R01 EB017742
6 · The paper itself

Abstract

Extended-release gastrointestinal (GI) luminal delivery substantially increases the ease of administration of drugs and consequently the adherence to therapeutic regimens. However, because of clearance by intrinsic GI motility, device gastroretention and extended drug release over a prolonged duration are very challenging. Here, we report that GI parasite-inspired active mechanochemical therapeutic grippers, or theragrippers, can reside within the GI tract of live animals for 24 hours by autonomously latching onto the mucosal tissue. We also observe a notable sixfold increase in the elimination half-life using theragripper-mediated delivery of a model analgesic ketorolac tromethamine. These results provide first-in-class evidence that shape-changing and self-latching microdevices enhance the efficacy of extended drug delivery.

Indexed as

Drug Delivery SystemsKetorolac TromethamineAnimalsDrug LiberationGastrointestinal TractPharmaceutical PreparationsKetorolac TromethaminePharmaceutical Preparations

Identifiers

PMID33115736
PMCPMC7608789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.