ArticleScience advances2020
Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
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- Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis-Mediated ETC Collapse and TXK-STAT3/PLCγ1 Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nanoparticle Delivery Systems in Rheumatoid Arthritis: More Than Vehicles.Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- TGF-β signaling mediates crosstalk between CD8Journal of biomedical science · 2026Article
- Itreg cells Ameliorates MOG-induced brain inflammation via endowing DC tolerogenic capacity predominantly via TGF-beta signaling mediated AKT/mTOR pathway inhibition.Molecular medicine (Cambridge, Mass.) · 2025Article
- Single mutation tunes IRF4 function and mediates B cell character to ameliorate murine lupus.iScience · 2025Article
- Article
- Aberrant Subsets of Regulatory T Cells and their Correlations with Serum IL-2 in Patients with Rheumatoid Arthritis.Inflammation · 2025Article
- Adaptive Immune Dyshomeostasis as a Mediator of Vascular Cognitive Decline: Unraveling Neurovascular Crosstalk.Aging and disease · 2025Review
- Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications.Frontiers in immunology · 2025Review
- miRNA-148a-containing GMSC-derived EVs modulate Treg/Th17 balance via IKKB/NF-κB pathway and treat a rheumatoid arthritis model.JCI insight · 2024Article
- Infusion of GMSCs relieves autoimmune arthritis by suppressing the externalization of neutrophil extracellular traps via PGE2-PKA-ERK axis.Journal of advanced research · 2024Article
- Infusion of GMSCs relieves autoimmune arthritis by suppressing the externalization of neutrophil extracellular traps via PGE2-PKA-ERK axis.Journal of advanced research · 2024Article
- Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics.Journal of translational medicine · 2024Article
- Autoimmunity and Carcinogenesis: Their Relationship under the Umbrella of Autophagy.Biomedicines · 2023Review
- Article
- Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Treg-targeted efficient-inducible platform for collagen-induced arthritis treatment.Materials today. Bio · 2023Article
- Carnosol Alleviates Collagen-Induced Arthritis by Inhibiting Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells.BioMed research international · 2023Article
- Cold air plasma improving rheumatoid arthritis via mitochondrial apoptosis pathway.Bioengineering & translational medicine · 2023Article
Corrections and comments
- Commented on byInduced T2021
Authors and funding
20 authors at 4 institutions in 2 countries.
Sujuan YangDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0003-0925-4501
Ximei ZhangDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0002-7286-214X
Jingrong ChenDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Junlong DangDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Rongzhen LiangDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Donglan ZengDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Huan ZhangDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Youqiu XueDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Yan LiuDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0003-1468-0898
Wenbin WuDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Jun ZhaoDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0001-9724-7226
Julie WangDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Yunfeng PanDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Hanshi XuDepartment of Internal Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Bing SunDepartment of Immunology, Institute of Biochemistry at Chinese Academy of Science, Shanghai 200031, China.
Feng HuangDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Yan LuDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0002-5893-6114
Willa HsuehDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Nancy OlsenDepartment of Medicine, The Penn State University Hershey Medical Center, Hershey, PA 17033, USA.ORCID 0000-0002-6588-3364
Song Guo ZhengDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. songguozheng2013@yahoo.com.ORCID 0000-0002-5611-4774
Sun Yat-sen University · CNThe Ohio State University Wexner Medical Center · USPenn State Milton S. Hershey Medical Center · USShanghai Institute of Applied Physics · CN
Funding
Therapeutic immunoregulation mediated by TGF-??-induced iTregs in autoimmune arthR01AR059103 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JARJOUR, WAEL N · 2010 to 2020
$3.9MImpact of the Adipose Tissue Microenvironment on AtherosclerosisR01HL135622 · NHLBI · OHIO STATE UNIVERSITY · PI HSUEH, WILLA A · 2018 to 2021
$2.1MBiophysics of fluid lipid/protein membrane domains and immune cell signalingR21AI073409 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BAUMGART, TOBIAS · 2008 to 2009
$401kNHLBI NIH HHS R01 HL135622NIAID NIH HHS R21 AI073409NIAMS NIH HHS R01 AR059103
Abstract
Aberrant number and/or dysfunction of CD4
Indexed as
Arthritis, ExperimentalArthritis, RheumatoidAnimalsFibroblastsForkhead Transcription FactorsHumansPhenotypeT-Lymphocytes, RegulatoryForkhead Transcription Factors
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.