Evidence map›Paper›PMID 33115680›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021

Serological cross-reaction and coinfection of dengue and COVID-19 in Asia: Experience from Indonesia.

Sri Masyeni, Marsha S Santoso, Putu Dyah Widyaningsih, Dg Wedha Asmara, Firzan Nainu, Harapan Harapan, R Tedjo Sasmono

Abstract readCase Reports
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  16. Severe dengue in the intensive care unit.Journal of intensive medicine · 2024
    Review
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  20. Co-Infection between Dengue Virus and SARS-CoV-2 in Cali, Colombia.The American journal of tropical medicine and hygiene · 2023
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sri MasyeniDepartment of Internal Medicine, Faculty of Medicine and Health Sciences Universitas Warmadewa, Denpasar, Bali 80235, Indonesia; Department of Internal Medicine, Sanjiwani Hospital, Denpasar, Bali 80235, Indonesia. Electronic address: masyeniputu@yahoo.com.
Marsha S SantosoEijkman Institute for Molecular Biology, Jakarta 10430, Indonesia. Electronic address: marshasantoso@eijkman.go.id.
Putu Dyah WidyaningsihDepartment of Internal Medicine, Faculty of Medicine and Health Sciences Universitas Warmadewa, Denpasar, Bali 80235, Indonesia; Department of Internal Medicine, Sanjiwani Hospital, Denpasar, Bali 80235, Indonesia. Electronic address: dr.putudyah@gmail.com.
Dg Wedha AsmaraDepartment of Internal Medicine, Faculty of Medicine and Health Sciences Universitas Warmadewa, Denpasar, Bali 80235, Indonesia; Department of Internal Medicine, Sanjiwani Hospital, Denpasar, Bali 80235, Indonesia. Electronic address: on.wedha@gmail.com.
Firzan NainuFaculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia. Electronic address: firzannainu@unhas.ac.id.
Harapan HarapanMedical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Infectious Disease Laboratory, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia. Electronic address: harapan@unsyiah.ac.id.
R Tedjo SasmonoEijkman Institute for Molecular Biology, Jakarta 10430, Indonesia. Electronic address: sasmono@eijkman.go.id.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Similar symptoms and laboratory findings between dengue and coronavirus disease 2019 (COVID-19) pose a diagnostic challenge in some dengue-endemic countries in Asia. In this study, we reported three cases of suspected COVID-19-dengue coinfection in hospitals of Bali, Indonesia. Serological data demonstrated that patients with positive results for dengue virus (DENV) NS1 antigen and anti-dengue IgM were also reactive to COVID-19 rapid antibody tests, suggesting dengue-COVID-19 coinfection. However, two patients were later confirmed negative for SARS-COV-2 by qRT-PCR, implying a plausible cross-reactivity of anti-dengue and anti-COVID-19 antibodies in the serological test. Coinfection of dengue and COVID-19 was evident in one patient, following confirmation of SARS-COV-2 by qRT-PCR and DENV infection using the NS1 antigen serology test. This case was the first case of dengue and COVID-19 coinfection in Indonesia and revealed possible cross-reactivity between SARS-COV-2 and DENV antibodies based on rapid serological tests. Our study indicates a public health concern regarding COVID-19 and dengue detection in Indonesia as well as in other dengue-endemic countries, and it is important for these nations to manage both pathogens concurrently.

Indexed as

COVID-19 Serological TestingAdultAgedAntibodies, ViralCoinfectionCOVID-19Cross ReactionsDengueDengue VirusFemaleHumansMiddle AgedSARS-CoV-2Antibodies, ViralCo-InfectionCOVID-19Cross-ReactivityDengueMisdiagnosisMixed-Infection

Identifiers

PMID33115680
PMCPMC7585717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.