Evidence map›Paper›PMID 33115534›Full record

ArticleActa neuropathologica communications2020

Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.

Chenan Zhang, Quinn T Ostrom, Eleanor C Semmes, Vijay Ramaswamy, Helen M Hansen, Libby Morimoto, Adam J de Smith, Melike Pekmezci, Zalman Vaksman, Hakon Hakonarson and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

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  14. Epidemiology of Brain and Other CNS Tumors.Current neurology and neuroscience reports · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Chenan ZhangDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, USA.
Quinn T OstromDepartment of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, USA.
Eleanor C SemmesMedical Scientist Training Program, Duke University School of Medicine, Durham, USA.
Vijay RamaswamyThe Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Canada.
Helen M HansenDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, USA.
Libby MorimotoSchool of Public Health, University of California, Berkeley, Berkeley, USA.
Adam J de SmithCenter for Genetic Epidemiology, University of Southern California, Los Angeles, USA.
Melike PekmezciDepartment of Pathology, University of California, San Francisco, San Francisco, USA.
Zalman VaksmanDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sharon J DiskinDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Catherine MetayerSchool of Public Health, University of California, Berkeley, Berkeley, USA.
Glioma International Case-Control Study (GICC)
Michael D TaylorThe Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Canada.
Joseph L WiemelsCenter for Genetic Epidemiology, University of Southern California, Los Angeles, USA.
Melissa L BondyDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Kyle M WalshDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, USA. Kyle.Walsh@Duke.edu.ORCID 0000-0002-5879-9981
Children's Hospital of Philadelphia · USDuke University · USUniversity of California, San Francisco · USUniversity of Southern California · USHospital for Sick Children · CA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Targeted Alpha-Particle Radiotheraphy of Brain Tumors with 211At-81C6 AntibodyP50CA190991 · NCI · DUKE UNIVERSITY · PI SAMPSON, JOHN H. · 2014 to 2023
$20.8M
GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5M
International Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Genetic Susceptibility to Pediatric Glioma inIndividuals and Diverse populationsR01CA194189 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WALSH, KYLE M, WIEMELS, JOSEPH LEO · 2015 to 2020
$5.0M
NCCDPHP CDC HHS NU58DP006344NCI NIH HHS CA139020NCI NIH HHS CA190991NCI NIH HHS CA52689NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS P30 CA008748NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA194189NCI NIH HHS T32 CA151022NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

Ependymoma is the third most common brain tumor in children, with well-described molecular characterization but poorly understood underlying germline risk factors. To investigate whether genetic predisposition to longer telomere length influences ependymoma risk, we utilized case-control data from three studies: a population-based pediatric and adolescent ependymoma case-control sample from California (153 cases, 696 controls), a hospital-based pediatric posterior fossa type A (EPN-PF-A) ependymoma case-control study from Toronto's Hospital for Sick Children and the Children's Hospital of Philadelphia (83 cases, 332 controls), and a multicenter adult-onset ependymoma case-control dataset nested within the Glioma International Case-Control Consortium (GICC) (103 cases, 3287 controls). In the California case-control sample, a polygenic score for longer telomere length was significantly associated with increased risk of ependymoma diagnosed at ages 12-19 (P = 4.0 × 10

Indexed as

Acid Anhydride HydrolasesAcylphosphataseAdolescentAdultAge of OnsetBrain NeoplasmsCase-Control StudiesChildDNA HelicasesEpendymomaFemaleGenetic Predisposition to DiseaseHumansInfratentorial NeoplasmsMaleMendelian Randomization AnalysisAcid Anhydride HydrolasesAcylphosphataseACYP2 protein, humanCtc1 protein, humanDNA HelicasesNAF1 protein, humanRibonucleoproteinsRNARTEL1 protein, humanStn1 protein, humanTelomerasetelomerase RNATelomere-Binding ProteinsTERT protein, humanEpendymomaMendelian randomizationPediatric cancerTelomere length

Identifiers

PMID33115534
PMCPMC7592366
OpenAlexW3094811716

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.