Evidence map›Paper›PMID 33115519›Full record

ArticleMolecular neurodegeneration2020

Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.

Vaishnavi S Jadhav, Peter B C Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K Atwood, Shweta S Puntambekar and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurodegeneration, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 94 citations in OpenAlex.

  1. Review
  2. Review
  3. Pediatric discovery · 2025
    Article
  4. Article
  5. Roles of TREM2 in Alzheimer's disease.Translational neurodegeneration · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Synapse Regulation.Advances in neurobiology · 2024
    Review
  14. Article
  15. Review
  16. Microglial TREM2 at the Intersection of Brain Aging and Alzheimer's Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Vaishnavi S JadhavPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Peter B C LinPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Taylor PenningtonPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Gonzalo Viana Di PriscoPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Asha Jacob JannuDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, 462020, USA.
Guixiang XuPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Miguel MoutinhoPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Jie ZhangDepartment of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Brady K AtwoodPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Shweta S PuntambekarPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Stephanie J BisselPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Adrian L OblakPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Gary E LandrethPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Bruce T LambPaul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA. btlamb@iu.edu.
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

The IU/JAX Alzheimer's Disease Precision Models Center: Rat F344U54AG054345 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Gregory W Carter · 2016 to 2026
$95.6M
Central and Peripheral Roles of TREM2 in Alzheimer's DiseaseRF1AG051495 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LAMB, BRUCE T, LANDRETH, GARY E. · 2015 to 2015
$3.6M
NIA NIH HHS RF1 AG051495NIA NIH HHS U54 AG054345
6 · The paper itself

Abstract

backgroundTriggering receptor expressed on myeloid cells 2 (TREM2) is expressed in the brain exclusively on microglia and genetic variants are linked to neurodegenerative diseases including Alzheimer's disease (AD), frontotemporal dementia (FTD) and Nasu Hakola Disease (NHD). The Trem2 variant R47H, confers substantially elevated risk of developing late onset Alzheimer's disease, while NHD-linked Trem2 variants like Y38C, are associated with development of early onset dementia with white matter pathology. However, it is not known how these Trem2 species, predisposes individuals to presenile dementia.

methodsTo investigate if Trem2 Y38C or loss of Trem2 alters neuronal function we generated a novel mouse model to introduce the NHD Trem2 Y38C variant in murine Trem2 using CRISPR/Cas9 technology. Trem2

resultsWhile mice harboring the Trem2 Y38C exhibited normal expression levels of TREM2, the pathological outcomes phenocopied Trem2

conclusionOur findings provide in vivo evidence that Trem2 Y38C disrupts normal TREM2 functions. Trem2

Indexed as

Alzheimer DiseaseAnimalsDisease Models, AnimalMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutMicrogliaMutationNeuronal PlasticityNeuronsReceptors, ImmunologicSynapsesMembrane GlycoproteinsReceptors, ImmunologicTrem2 protein, mouseEarly-onset dementiaNHDOligodendrocytes/myelinSynaptic lossSynaptic plasticityTranscriptomicsTrem2-Y38C

Identifiers

PMID33115519
PMCPMC7594478
OpenAlexW3096624780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.