Evidence map›Paper›PMID 33115484›Full record

Trial reportFluids and barriers of the CNS2020

Permeability of the windows of the brain: feasibility of dynamic contrast-enhanced MRI of the circumventricular organs.

Inge C M Verheggen, Joost J A de Jong, Martin P J van Boxtel, Alida A Postma, Frans R J Verhey, Jacobus F A Jansen, Walter H Backes

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Fluids and barriers of the CNS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Sex differences in central salt sensing in the human brain.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  2. Review
  3. Article
  4. Metabolic Endotoxemia: From the Gut to Neurodegeneration.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Inge C M Verheggen *Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. inge.verheggen@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0001-7749-5994
Joost J A de Jong *School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, The Netherlands.
Martin P J van BoxtelDepartment of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Alida A PostmaSchool for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, The Netherlands.
Frans R J VerheyDepartment of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Jacobus F A JansenSchool for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, The Netherlands.
Walter H BackesSchool for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, The Netherlands.

Funding

EPA EP-C-15-031
6 · The paper itself

Abstract

backgroundCircumventricular organs (CVOs) are small structures without a blood-brain barrier surrounding the brain ventricles that serve homeostasic functions and facilitate communication between the blood, cerebrospinal fluid and brain. Secretory CVOs release peptides and sensory CVOs regulate signal transmission. However, pathogens may enter the brain through the CVOs and trigger neuroinflammation and neurodegeneration. We investigated the feasibility of dynamic contrast-enhanced (DCE) MRI to assess the CVO permeability characteristics in vivo, and expected significant contrast uptake in these regions, due to blood-brain barrier absence.

methodsTwenty healthy, middle-aged to older males underwent brain DCE MRI. Pharmacokinetic modeling was applied to contrast concentration time-courses of CVOs, and in reference to white and gray matter. We investigated whether a significant and positive transfer from blood to brain could be measured in the CVOs, and whether this differed between secretory and sensory CVOs or from normal-appearing brain matter.

resultsIn both the secretory and sensory CVOs, the transfer constants were significantly positive, and all secretory CVOs had significantly higher transfer than each sensory CVO. The transfer constants in both the secretory and sensory CVOs were higher than in the white and gray matter.

conclusionsCurrent measurements confirm the often-held assumption of highly permeable CVOs, of which the secretory types have the strongest blood-to-brain transfer. The current study suggests that DCE MRI could be a promising technique to further assess the function of the CVOs and how pathogens can potentially enter the brain via these structures.

trial registrationNetherlands Trial Register number: NL6358, date of registration: 2017-03-24.

Indexed as

AgedAged, 80 and overCircumventricular OrgansContrast MediaFeasibility StudiesGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedWhite MatterContrast MediaCircumventricular organsDynamic contrast-enhanced magnetic resonance imagingPermeabilityPharmacokinetic modeling

Identifiers

PMID33115484
PMCPMC7594295

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.