ArticleBMC infectious diseases2020
Comparing intervention strategies for reducing Clostridioides difficile transmission in acute healthcare settings: an agent-based modeling study.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Molecular epidemiology and clinical differentiation betweenAntimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- An agent-based model on antimicrobial de-escalation in intensive care units: Implications on clinical trial design.PloS one · 2024Article
- Early coronavirus disease 2019 (COVID-19) pandemic effects on individual-level risk for healthcare-associated infections in hospitalized patients.Infection control and hospital epidemiology · 2023Article
- Combining a parsimonious mathematical model with infection data from tailor-made experiments to understand environmental transmission.Scientific reports · 2023Article
- Systematic Design of Adenosine Analogs as Inhibitors of aJournal of medicinal chemistry · 2023Article
- Evaluating the impact of testing strategies for the detection of nosocomial COVID-19 in English hospitals through data-driven modeling.Frontiers in medicine · 2023Article
- A review of epidemiological models of Clostridioides difficile transmission and control (2009-2021).Anaerobe · 2022Review
- Progress Report: Antimicrobial Drug Discovery in the Resistance Era.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Inactivation of Spores and Vegetative Forms ofInternational journal of environmental research and public health · 2022Review
- Mathematically modeling the effect of touch frequency on the environmental transmission of Clostridioides difficile in healthcare settings.Mathematical biosciences · 2021Article
- Evaluating intervention strategies in controlling coronavirus disease 2019 (COVID-19) spread in care homes: An agent-based model.Infection control and hospital epidemiology · 2021Article
- Modeling transmission of pathogens in healthcare settings.Current opinion in infectious diseases · 2021Review
- Clostridioides Difficile: A Concise Review of Best Practices and Updates.Journal of primary care & community healthReview
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundClostridioides difficile infection (CDI) is one of the most common healthcare infections. Common strategies aiming at controlling CDI include antibiotic stewardship, environmental decontamination, and improved hand hygiene and contact precautions. Mathematical models provide a framework to evaluate control strategies. Our objective is to evaluate the effectiveness of control strategies in decreasing C. difficile colonization and infection using an agent-based model in an acute healthcare setting.
methodsWe developed an agent-based model that simulates the transmission of C. difficile in medical wards. This model explicitly incorporates healthcare workers (HCWs) as vectors of transmission, tracks individual patient antibiotic histories, incorporates varying risk levels of antibiotics with respect to CDI susceptibility, and tracks contamination levels of ward rooms by C. difficile. Interventions include two forms of antimicrobial stewardship, increased environmental decontamination through room cleaning, improved HCW compliance, and a preliminary assessment of vaccination.
resultsIncreased HCW compliance with CDI patients was ranked as the most effective intervention in decreasing colonizations, with reductions up to 56%. Antibiotic stewardship practices were highly ranked after contact precaution compliance. Vaccination and reduction of high-risk antibiotics were the most effective intervention in decreasing CDI. Vaccination reduced CDI cases to up to 90%, and the reduction of high-risk antibiotics decreased CDI cases up to 23%.
conclusionsOverall, interventions that decrease patient susceptibility to colonization by C. difficile, such as antibiotic stewardship, were the most effective interventions in reducing both colonizations and CDI cases.
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