Evidence map›Paper›PMID 33114922›Full record

ArticleOptics express2020

3D computational cannula fluorescence microscopy enabled by artificial neural networks.

Ruipeng Guo, Zhimeng Pan, Andrew Taibi, Jason Shepherd, Rajesh Menon

Abstract read
In one paragraph

Article in Optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruipeng Guo
Zhimeng Pan
Andrew Taibi
Jason Shepherd
Rajesh Menon

Funding

Expanding field-of-view with reduced tissue displacement in micro-endoscopic computational imagingR21EY030717 · NEI · UNIVERSITY OF UTAH · PI BLAIR, STEVEN M, MENON, RAJESH · 2019 to 2019
$457k
NEI NIH HHS R21 EY030717
6 · The paper itself

Abstract

Computational cannula microscopy (CCM) is a high-resolution widefield fluorescence imaging approach deep inside tissue, which is minimally invasive. Rather than using conventional lenses, a surgical cannula acts as a lightpipe for both excitation and fluorescence emission, where computational methods are used for image visualization. Here, we enhance CCM with artificial neural networks to enable 3D imaging of cultured neurons and fluorescent beads, the latter inside a volumetric phantom. We experimentally demonstrate transverse resolution of ∼6µm, field of view ∼200µm and axial sectioning of ∼50µm for depths down to ∼700µm, all achieved with computation time of ∼3ms/frame on a desktop computer.

Indexed as

Neural Networks, ComputerAnimalsCannulaCatheters, IndwellingCells, CulturedEquipment DesignHippocampusImage EnhancementImaging, Three-DimensionalMiceMicroscopy, FluorescenceMicrospheresNeuroimagingNeuronsPhantoms, Imaging

Identifiers

PMID33114922
PMCPMC7679189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.