Evidence map›Paper›PMID 33114727›Full record

ArticleInternational journal of molecular sciences2020

Antitumor Activity of the Cardiac Glycoside αlDiginoside by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells.

Jing-Ru Weng, Wei-Yu Lin, Li-Yuan Bai, Jing-Lan Hu, Chia-Hsien Feng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Jing-Ru WengDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.ORCID 0000-0003-4934-9126
Wei-Yu LinDepartment of Pharmacy, Kinmen Hospital, Kinmen 89142, Taiwan.
Li-Yuan BaiDivision of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan.
Jing-Lan HuDivision of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan.
Chia-Hsien FengDepartment of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
China Medical University · TWKaohsiung Medical University · TWNational Quemoy University · TWNational Sun Yat-sen University · TW

Funding

Ministry of Health and Welfare, China Medical University Hospital Cancer Research Center of Excellence MOHW109-TDU-B-212-010001Ministry of Science and Technology MOST 106-2320-B-110-003-MY3
6 · The paper itself

Abstract

We recently isolated a cardiac glycoside (CG), αldiginoside, from an indigenous plant in Taiwan, which exhibits potent tumor-suppressive efficacy in oral squamous cell carcinoma (OSCC) cell lines (SCC2095 and SCC4, IC

Indexed as

Antineoplastic Agents, PhytogenicCarcinoma, Squamous CellCardiac GlycosidesCell Cycle CheckpointsCell Line, TumorCell ProliferationCell SurvivalDown-RegulationGene Expression Regulation, NeoplasticHumansMouth NeoplasmsMyeloid Cell Leukemia Sequence 1 ProteinProteolysisSignal TransductionAntineoplastic Agents, PhytogenicCardiac GlycosidesMCL1 protein, humanMyeloid Cell Leukemia Sequence 1 Proteinapoptosiscardiac glycosidecell-cycle arrestMcl-1oral squamous cell carcinomaαldiginoside

Identifiers

PMID33114727
PMCPMC7663359
OpenAlexW3096966067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.