ArticleMaterials (Basel, Switzerland)2020
Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material.
Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of Different Types of Calcium Sulfate Hydrates Incorporated into Dental Calcium Silicate Cement on Hardening, Flow, Anti-Washout, and Biological Properties.Materials (Basel, Switzerland) · 2026Article
- Setting Characteristics, Solubility, Bioactivity and Interaction with Dentin of Four Calcium Silicate-Based Endodontic Sealers.Journal of functional biomaterials · 2026Article
- Biocompatibility and bioactivity of bioceramic endodontic sealer: NeoSealer Flo.Journal of applied oral science : revista FOB · 2025Article
- Impact of various endodontic sealers on HPDLF Cell viability and apoptosis.Scientific reports · 2024Article
- Stereomicroscopic evaluation of sealing ability of four different root canal sealers: an in-vitro study.BMC oral health · 2024Article
- Biological Properties of Bioceramic Sealers on Osteoblastic Cells: A Comparative Study.Brazilian dental journal · 2024Article
- Evaluation of Cytotoxicity, Cell Attachment, and Elemental Characterization of Three Calcium Silicate-Based Sealers.Materials (Basel, Switzerland) · 2023Article
- Hydraulic calcium silicate-based root canal sealers mitigate proinflammatory cytokine synthesis and promote osteogenesisJournal of dental sciences · 2023Article
- Characterisation of the Bioactivity and the Solubility of a New Root Canal Sealer.International dental journal · 2023Article
- Fabrication and characterisation of novel algin incorporated bioactive-glass 58S calcium-silicate-based root canal sealer.Journal of dental sciences · 2023Article
- Bioactivity Potential of Bioceramic-Based Root Canal Sealers: A Scoping Review.Life (Basel, Switzerland) · 2022Article
- The thermoplastic techniques or single-cone technique on the quality of root canal filling with tricalcium silicate-based sealer: An integrative review.Journal of clinical and experimental dentistry · 2022Review
- Special Issue: Advances in Dental Bio-Nanomaterials.Materials (Basel, Switzerland) · 2022Article
- Physicochemical Properties of Two Generations of MTA-Based Root Canal Sealers.Materials (Basel, Switzerland) · 2021Article
- Investigating the Effect of Selenium Nanoparticles on Mineral Trioxide Aggregates as a Promising Novel Dental Material.Journal of International Society of Preventive & Community DentistryArticle
- Tissue repair capacity of bioceramic endodontic sealers in rat subcutaneous tissue.Brazilian dental journalArticle
- Toxicity of bioceramic and resinous endodontic sealers using an alternative animal model:Journal of conservative dentistry : JCDArticle
- Response of periodontal ligament stem cells to lipopolysaccharide and calcium silicate-based materials.Brazilian dental journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Bio-C Sealer is a recently developed high-plasticity, calcium-silicate-based, ready-to-use material. In the present study, chemical elements of the materials were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The biocompatibility of the Bio-C Sealer was investigated using cytotoxicity tests and histological responses in the roots of dogs' teeth. XRD, SEM, and FTIR produced hydrated calcium silicate in the presence of water molecules. In addition, FTIR showed the formation of calcium hydroxide and polyethylene glycol, a dispersing agent. The 1:4 dilutions of Bio-C Sealer presented weaker cytotoxicity than the Calcipex II in an in vitro system using the V-79 cell line. After 90 d, the periradicular tissue response of beagle dog roots was histologically evaluated. Absence of periradicular inflammation was reported in 17 of the 18 roots assessed with the Bio-C Sealer, whereas mature vertical periodontal ligament fibers were observed in the apical root ends filled with the Bio-C Sealer. Based on these results and previous investigations, the Bio-C Sealer is recommended as an effective root-end filling material. These results are relevant for clinicians considering the use of Bio-C Sealer for treating their patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.